Plasticity of 5-HT2A Serotonin Receptor in Patients With Analgesic-Induced Transformed Migraine
Article first published online: 11 JUN 2003
Headache: The Journal of Head and Face Pain
Volume 38, Issue 7, pages 534–539, July 1998
How to Cite
Srikiatkhachorn, A., Puangniyom, S. and Govitrapong, P. (1998), Plasticity of 5-HT2A Serotonin Receptor in Patients With Analgesic-Induced Transformed Migraine. Headache: The Journal of Head and Face Pain, 38: 534–539. doi: 10.1046/j.1526-4610.1998.3807534.x
- Issue published online: 11 JUN 2003
- Article first published online: 11 JUN 2003
- Accepted for publication December 18, 1997.
- transformed migraine;
- 5-HT2A serotonin receptor;
Chronic drug exposure can induce a significant change in neurotransmitter receptor systems and is possibly involved in the pathogenesis of drug-induced neurological disorders. Abuse of analgesics is known to induce deterioration in headache status in patients with primary headaches, especially migraine. To assess the possibility of 5-HT2A serotonin receptor plasticity in this condition, we investigated receptor binding on the platelet membrane in patients with analgesic-induced transformed migraine, patients with migraine, and nonheadache controls. Various concentrations of [3H]-spiperone (0.4 to 12 nmol) was used as a radioligand, and ketanserin was used to determine nonspecific binding. A lower maximal number of receptors (Bmax) was observed in patients with migraine as compared to patients with transformed migraine, and controls (467 ± 58, 708 ± 36, and 786 ± 64 fmol/mg protein, respectively, P<0.01); whereas the value of the dissociation equilibrium constant (Kd) remained unchanged (1.72 ± 0.16, 1.41 ± 0.13, and 1.25 ± 0.21 nmol for patients with migraine, patients with transformed migraine, and nonheadache controls, respectively). A significant decrease in Bmax value was observed in patients with transformed migraine after 4 weeks of analgesic withdrawal (770 ± 25 and 345 ± 31 fmol/mg protein, P<0.001), whilst no significant change in Kd value was observed (1.95 ± 0.12 and 2.47 ± 0.30 nmol, respectively). These findings indicate that 5-HT2A serotonin receptor system is altered in patients with transformed migraine with analgesic overuse. Such receptor plasticity may be an important step in the pathogenic mechanism of transformed migraine.