Significance of Migrainous Features in Cluster Headache: Divalproex Responsiveness


Address all correspondence to Dr. Steve D. Wheeler, Neurologic Center of South Florida, 8940 North Kendall Drive, 802-E, Miami, FL 33176.


Two patients with cluster headache and prominent migrainous features are described and a shared migraine and cluster headache pathophysiology is discussed. Both patients failed routine cluster headache pharmacotherapy, one failed multiple operative interventions; however, both remitted on divalproex. It is suggested that migrainous features be assessed in cluster headache and divalproex initiated before pursuing invasive procedures.