Prostaglandin Analog Mechanisms Are Not Effective in Refractory Chronic Cluster Headache
Article first published online: 12 JUN 2003
Headache: The Journal of Head and Face Pain
Volume 38, Issue 8, pages 618–620, September 1998
How to Cite
Evers, S., Masur, H., Sörös, P., Brilla, R. and Husstedt, I.-W. (1998), Prostaglandin Analog Mechanisms Are Not Effective in Refractory Chronic Cluster Headache. Headache: The Journal of Head and Face Pain, 38: 618–620. doi: 10.1046/j.1526-4610.1998.3808618.x
- Issue published online: 12 JUN 2003
- Article first published online: 12 JUN 2003
- Accepted for publication February 4, 1998.
- Cited By
- prostaglandin E;
- chronic cluster headache
Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 μg misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.