A complete list of the participants in this research study appears at the end of the article.
Oral Rizatriptan Versus Oral Sumatriptan: A Direct Comparative Study in the Acute Treatment of Migraine
Article first published online: 31 MAY 2002
Headache: The Journal of Head and Face Pain
Volume 38, Issue 10, pages 748–755, November 1998
How to Cite
Tfelt-Hansen, P., Teall, J., Rodriguez, F., Giacovazzo, M., Paz, J., Malbecq, W., Block, G. A., Reines, S. A. and Visser, W. H. (1998), Oral Rizatriptan Versus Oral Sumatriptan: A Direct Comparative Study in the Acute Treatment of Migraine. Headache: The Journal of Head and Face Pain, 38: 748–755. doi: 10.1046/j.1526-4610.1998.3810748.x
- Issue published online: 31 MAY 2002
- Article first published online: 31 MAY 2002
- Accepted for publication September 16, 1998.
Rizatriptan is a potent, oral, 5-HT1B/1D agonist with more rapid absorption and higher bioavailability than oral sumatriptan. It was postulated that this would result in more rapid onset of effect. This randomized, double-blind, triple-dummy, parallel-groups study compared rizatriptan 5 mg, rizatriptan 10 mg, sumatriptan 100 mg, and placebo in 1268 outpatients treating a single migraine attack. Headache relief rates after rizatriptan 10 mg were consistently higher than sumatriptan at all time points up to 2 hours, with significance at 1 hour (37% versus 28%, P=0.010). All active agents were significantly superior to placebo with regard to headache relief and pain freedom at 2 hours (P≤0.001). The primary efficacy endpoint of time to pain relief through 2 hours demonstrated that, after adjustment for age imbalance, rizatriptan 10 mg had earlier onset than sumatriptan 100 mg (P=0.032; hazard ratio 1.21). Rizatriptan 10 mg was also superior to sumatriptan on pain-free response (P=0.032), reduction in functional disability (P=0.015), and relief of nausea at 2 hours (P=0.010). Significantly fewer drug-related clinical adverse events were reported after rizatriptan 10 mg (33%, P=0.014) compared with sumatriptan 100 mg (41%). We conclude that rizatriptan 10 mg has a rapid onset of action and relieves headache and associated symptoms more effectively than sumatriptan 100 mg.