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Amino Acids in the Saliva of Patients With Migraine

Authors

  • C. Rajda MD,

    1. From the Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and
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  • J. Tajti MD, PhD,

    1. From the Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and
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  • R. Komoróczy MSc,

    1. Cereal Research Company (Komoróczy), Szeged, Hungary.
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  • E. Seres MD,

    1. From the Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and
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  • P. Klivényi MD,

    1. From the Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and
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  • L. Vécsei MD, PhD, DSc

    Corresponding author
    1. From the Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary (Rajda, Tajti, Seres, Klivényi, and Vécsei), and
      Address all correspondence to Professor László Vécsei, Department of Neurology, Albert Szent-Györgyi Medical University, PO Box 71, H-6701 Szeged, Hungary.
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Address all correspondence to Professor László Vécsei, Department of Neurology, Albert Szent-Györgyi Medical University, PO Box 71, H-6701 Szeged, Hungary.

Abstract

There are a number of hypotheses concerning the pathogenesis of migraine, but they are frequently conflicting. In addition to the vascular hypothesis, clinical data are available that excitatory amino acids may play an important role in the development of the disease. In this study, free amino acid concentrations were measured by RP-HPLC in the saliva of 23 migraineurs without aura, 14 migraineurs with aura, and 20 healthy subjects. Significantly higher concentrations of glutamic acid, serine, glycine, arginine, and tyrosine were found in the saliva samples of both groups of migraineurs relative to the control group. It is suggested that amino acids causing hyperexcitability in the central nervous system may be linked to the pathogenesis of migraine.

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