LASH: A Syndrome of Long-lasting Autonomic Symptoms With Hemicrania (A New Indomethacin- Responsive Headache)


Address all correspondence to Dr. Todd D. Rozen, Jefferson Headache Center, 111 South 11th Street, Suite 8130, Philadelphia, PA 19107.


A patient presented with a unique, stereotypical, episodic headache disorder marked by long-lasting autonomic symptoms with associated hemicrania (LASH). The autonomic symptoms clearly overshadowed the headache as the major component of the syndrome. Indomethacin controlled both the autonomic symptoms and the headache, suggesting that this is a new type of indomethacin-responsive headache. It may also complete the indomethacin-responsive headache spectrum.