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Assessing the Relative Incidence of Mitochondrial DNA A3243G in Migraine Without Aura With Maternal Inheritance

Authors

  • G. Di Gennaro MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
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  • M.G. Buzzi MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
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  • O. Ciccarelli MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Department of Neurological Sciences (Dr. Ciccarelli)
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  • F.M. Santorelli MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Istituto di Clinica delle Malattie Nervose e Mentali, La Sapienza University, Rome ( Drs. Santorelli, Pierelli, Fortini, Nappi and Casali)
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  • F. Pierelli MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Istituto di Clinica delle Malattie Nervose e Mentali, La Sapienza University, Rome ( Drs. Santorelli, Pierelli, Fortini, Nappi and Casali)
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  • D. Fortini PhD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Istituto di Clinica delle Malattie Nervose e Mentali, La Sapienza University, Rome ( Drs. Santorelli, Pierelli, Fortini, Nappi and Casali)
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  • M. D'onofrio MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
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  • A. Costa MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Laboratory of Molecular Neurobiology, IRCCS-Institute of Neurology C. Mondino, Headache Center, University of Pavia, Italy.(Dr. Costa and Nappi)
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  • G. Nappi MD,

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Istituto di Clinica delle Malattie Nervose e Mentali, La Sapienza University, Rome ( Drs. Santorelli, Pierelli, Fortini, Nappi and Casali)
    3. Laboratory of Molecular Neurobiology, IRCCS-Institute of Neurology C. Mondino, Headache Center, University of Pavia, Italy.(Dr. Costa and Nappi)
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  • C. Casali MD, PhD

    1. From IRCCS Neuromed, Pozzilli,(IS) (Drs. Di Gennaro, Buzzi, Pierelli, and D'Onofrio)
    2. Istituto di Clinica delle Malattie Nervose e Mentali, La Sapienza University, Rome ( Drs. Santorelli, Pierelli, Fortini, Nappi and Casali)
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Address all correspondence to Dr. Carlo Casali, Istituto di Clinica delle Malattie Nervose e Mentali, Università di Roma La Sapienza, Viale dell'Università 30, 00186 Rome, Italy.

Abstract

Objective.—To determine whether patients with migraine without aura with maternal “inheritance” are affected by a monosymptomatic form of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes) or carry the most common mitochondrial DNA (mtDNA) mutation associated with MELAS, namely the A3243G transition in the transfer RNA (tRNA)Leu(UUR) gene.

Background.—The association between migraine and abnormal mitochondrial function has been suggested on clinical, biochemical, and neuroradiological grounds. Migraine attacks with vomiting and cerebral infarctions, most often in the posterior cerebral regions, which are reminiscent of complicated migraine, are typical features of MELAS. The observation that migrainous patients have affected mothers more often than affected fathers suggests a possible role for maternally transmitted genetic factors.

Methods.—We studied 25 patients with migraine with aura whose mothers were also affected. A sensitive polymerase chain reaction restriction fragment length polymorphism analysis was used to detect mutated genomes.

Conclusions.—We failed to detect the MELAS mutation, but migraine may still be associated with point mutations of mtDNA other than A3243G or with as-yet-unidentified nuclear DNA factors related to mitochondrial function.

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