Is Blood Homocysteine Elevated in Migraine?
Article first published online: 9 OCT 2008
Headache: The Journal of Head and Face Pain
Volume 41, Issue 8, pages 779–781, September 2001
How to Cite
Hering-Hanit, R., Gadoth, N., Yavetz, A., Gavendo, S. and Sela, B. (2001), Is Blood Homocysteine Elevated in Migraine?. Headache: The Journal of Head and Face Pain, 41: 779–781. doi: 10.1046/j.1526-4610.2001.01143.x
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
- Accepted for publication April 12, 2001.
Objective.—To determine total serum homocysteine levels in a large group of patients with migraine with and without aura.
Background.—Hypercoagulable state is a known risk factor for stroke in the young. The existence of a hypercoagulable state has been postulated in migraine and homocysteinemia with young-onset stroke. To the best of our knowledge, blood homocysteine has not been studied in a significant number of patients with various forms of migraine.
Methods.—Total serum homocysteine was measured with high-performance liquid chromatography in 78 patients with migraine and in 126 age- and sex-matched healthy volunteers.
Results.—Seventy-eight patients aged 18 to 65 years were studied: 22 with migraine with aura and 56 with migraine without aura. Only 1 man had significantly elevated blood homocysteine (38.6 μmol/L), while another had a borderline elevation (15.8 μmol/L) (reference value for both sexes in our laboratory is 4 to 14 μmol/L). Both patients suffered from migraine without aura.
Conclusions.—Blood homocysteine is not elevated in migraine.