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Keywords:

  • nitric oxide;
  • nitroglycerin;
  • migraine;
  • aura

As a nitric oxide donor, nitroglycerin can trigger migraine in migraineurs. The headache is not characteristically accompanied by an aura.

A patient with no personal or family history of migraine reported the development of a typical visual aura and a throbbing headache while using nitroglycerin for angina pectoris.

The possible mechanisms are discussed.