Amitriptyline Treatment in Chronic Drug-Induced Headache: A Double-Blind Comparative Pilot Study
Article first published online: 20 DEC 2001
Headache: The Journal of Head and Face Pain
Volume 41, Issue 2, pages 178–182, February 2001
How to Cite
Descombes, S., Brefel-Courbon, C., Thalamas, C., Albucher, J.F., Rascol, O., Montastruc, J.L. and Senard, J.M. (2001), Amitriptyline Treatment in Chronic Drug-Induced Headache: A Double-Blind Comparative Pilot Study. Headache: The Journal of Head and Face Pain, 41: 178–182. doi: 10.1046/j.1526-4610.2001.111006178.x
- Issue published online: 27 JAN 2004
- Article first published online: 20 DEC 2001
- Accepted for publication September 3, 2000.
- chronic drug-induced headache;
- clinical trial;
- quality of life;
- analgesic abuse
Objective.—To assess the effects of amitriptyline and sudden analgesic withdrawal on headache frequency and quality of life in patients suffering from chronic daily headache related to analgesics abuse.
Methods.—Seventeen nondepressed patients with chronic drug-induced headache were included in a 9-week, parallel-group, randomized, double-blind, placebo-controlled study. After abrupt analgesic withdrawal, amitriptyline or an active placebo (trihexyphenidyl) was started. The primary efficacy variable was headache frequency recorded on a headache diary in the last 4 weeks of each treatment. The secondary efficacy variable was quality of life (Nottingham Health Profile).
Results.—Headache frequency decreased by 45% in the amitriptyline group and by 28% in the trihexyphenidyl group. Amitriptyline enhanced all the dimensions of quality of life and significantly improved emotional reaction and social isolation.
Conclusion.—This pilot study suggests a beneficial effect of amitriptyline on headache frequency and quality of life for patients with chronic drug-induced headache.