Objective.—To evaluate whether a particular genotype of the interleukin-1α (IL1A) gene affects the clinical features of migraine.
Background.—Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin-1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases.
Methods.—In a group of 269 patients with migraine, we tested the association of the −889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease.
Results.—Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly (P < .01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly (P < .05) more frequent in patients with migraine with aura than in patients with migraine without aura.
Conclusions.—The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.