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Keywords:

  • hemicrania continua;
  • celecoxib;
  • rofecoxib;
  • indomethacin;
  • COX-2 inhibitors

Background.—Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin. We report the treatment response to two cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, in a series of patients with hemicrania continua.

Methods.—Fourteen patients were treated, 9 with rofecoxib and 5 with celecoxib.

Results.—Three patients in each group had a complete response to treatment.

Conclusion.—The cyclooxygenase-2 inhibitors may represent an alternative to indomethacin in the treatment of hemicrania continua. Their mechanism of action for this potential indication is unknown.