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Hemicrania Continua Responds to Cyclooxygenase-2 Inhibitors


Address all correspondence to Dr. Mario F.P. Peres, São Paulo Headache Center, Al. Joaquim Eugenio de Lima, 881 cj 708 São Paulo, Brazil 01403-001; São Paulo, SP, Brazil.


Background.—Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin. We report the treatment response to two cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, in a series of patients with hemicrania continua.

Methods.—Fourteen patients were treated, 9 with rofecoxib and 5 with celecoxib.

Results.—Three patients in each group had a complete response to treatment.

Conclusion.—The cyclooxygenase-2 inhibitors may represent an alternative to indomethacin in the treatment of hemicrania continua. Their mechanism of action for this potential indication is unknown.