Intravenous Propofol in the Treatment of Refractory Headache
Article first published online: 9 OCT 2008
Headache: The Journal of Head and Face Pain
Volume 42, Issue 7, pages 638–641, July 2002
How to Cite
Mendes, P. M., Silberstein, S. D., Young, W. B., Rozen, T. D. and Paolone, M. F. (2002), Intravenous Propofol in the Treatment of Refractory Headache. Headache: The Journal of Head and Face Pain, 42: 638–641. doi: 10.1046/j.1526-4610.2002.02151.x
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
- Accepted for publication April 26, 2002.
- transformed migraine;
- chronic daily headaches;
- refractory headaches;
We analyzed the results of treating patients who had chronic daily headaches that were refractory to standard medications with repetitive low-dose boluses of intravenous propofol (2,6-diisopropylphenol).
Patients were treated over a 1-year period at Thomas Jefferson University Hospital. A total of 18 patients were treated a total of 21 times. Over 90% of patients had at least some headache relief after treatment. The headache cycle was broken in eight patients. There were no complications. Intravenous propofol is safe and effective when used under monitored conditions and should be considered for patients who have refractory chronic daily headache and have failed other interventions.