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Labetalol for Prophylactic Treatment of Intractable Migraine During Pregnancy

Authors

  • Ranjan Dey MD,

    1. From the Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • Sajid Khan MD,

    1. From the Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • Vimal Akhouri MD,

    1. From the Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • Joshua Wootton PhD,

    1. From the Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • Zahid H. Bajwa MD

    1. From the Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Address all correspondence to Dr. Zahid H. Bajwa, Department of Neurology, Harvard Medical School, Arnold Pain Center, Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115.

Abstract

Headaches tend to improve in the majority of migraineurs during pregnancy, but some patients report a worsening of migraine and present a management challenge because of the restrictions of pharmacotherapy during pregnancy. Treatment options become even more limited for pregnant migraineurs who develop preeclampsia. Labetalol was tried successfully in reducing the frequency, duration, and intensity of migraine attacks in a pregnant woman with preeclampsia. There were no significant side effects and the patient delivered a healthy baby without complications.

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