Familial Cluster Headache: A Series of 186 Index Patients


Address correspondence to Dr. M. El Amrani, Service de Neurologie, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. E-mail: mohamed.el-amrani@lrb.ap-hop-paris.fr.


Objective.—To investigate the familial occurrence of cluster headache in a series of French patients fulfilling the International Headache Society diagnosis criteria.

Methods.—One hundred eighty-six index patients and 624 first-degree relatives were surveyed.

Results.—A positive family history of cluster headache was found in 20 index patients (10.75%) with 22 affected first-degree relatives (3.4%). In multiplex families 6 of the 68 second-degree relatives that were contacted had cluster headache.

Conclusion.—No precise mode of inheritance could be drawn from the observed repartition of cases within multiplex families.