Safety of a Patented Special Butterbur Root Extract for Migraine Prevention
Article first published online: 14 JAN 2003
Headache: The Journal of Head and Face Pain
Volume 43, Issue 1, pages 76–78, January 2003
How to Cite
Danesch, U. and Rittinghausen, R. (2003), Safety of a Patented Special Butterbur Root Extract for Migraine Prevention. Headache: The Journal of Head and Face Pain, 43: 76–78. doi: 10.1046/j.1526-4610.2003.03015.x
- Issue published online: 14 JAN 2003
- Article first published online: 14 JAN 2003
- Accepted for publication September 23, 2002.
- Petasites hybridus;
- adverse effects
Objective To report on the safety of a patented special butterbur root extract used for migraine prevention.
Background Two placebo-controlled clinical trials have been conducted supporting the beneficial use in humans.
Methods Results from acute, subchronic and chronic animal toxicity studies as well as from mutagenicity studies are reported. Safety data gained from clinical trials, postmarketing surveillance studies and pharmacovigilance are evaluated and discussed.
Conclusion The patented special butterbur root extract is safe for the treatment in humans.