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Normalization of Serum Cortisol Concentration With Opioid Treatment of Severe Chronic Pain
Article first published online: 4 JUL 2002
DOI: 10.1046/j.1526-4637.2002.02019.x
1526-4637/asset/cover.gif?v=1&s=05db6b10ee16a1b692fde30702b8d979c1971d9d "Pain Medicine")
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How to Cite
Tennant, F. and Hermann, L. (2002), Normalization of Serum Cortisol Concentration With Opioid Treatment of Severe Chronic Pain. Pain Medicine, 3: 132–134. doi: 10.1046/j.1526-4637.2002.02019.x
Publication History
- Issue published online: 4 JUL 2002
- Article first published online: 4 JUL 2002
- Abstract
- Article
- References
- Cited By
Serum cortisol concentrations may be altered in severe, chronic pain due to excess stimulation of the hypothalamic-pituitary-adrenal axis. Among 40 consecutive patients with severe, chronic pain 26 (65.0%) demonstrated abnormal serum cortisol concentration. After 90 days of treatment, only 7 (17.5%; p<0.01) continued to show abnormal serum cortisol concentration indicating that serum cortisol and other serologic abnormalities may serve as biologic markers of severe, chronic pain.