Modafinil Treatment of Opioid-Induced Sedation†

  1. Lynn Webster MD1,
  2. Megan Andrews1,
  3. Gregory Stoddard , MPH2

Article first published online: 5 JUN 2003

DOI: 10.1046/j.1526-4637.2003.03014.x

Issue

Pain Medicine

Pain Medicine

Volume 4, Issue 2, pages 135–140, June 2003

Additional Information

How to Cite

Webster, L., Andrews, M. and Stoddard, G. (2003), Modafinil Treatment of Opioid-Induced Sedation. Pain Medicine, 4: 135–140. doi: 10.1046/j.1526-4637.2003.03014.x

Author Information

  1. 1

    Alpine Pain and Addiction Medicine, Salt Lake City, Utah;

  2. 2

    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah

*Reprint requests to: Lynn Webster, MD, Alpine Pain and Addiction Medicine, 617 East 3900 South, Salt Lake City, UT 84107. Tel: (801) 261-4988; Fax: (801) 261-8389; E-mail: lynnw@alpinemedical.com.

  1. †

    Funding for this study was provided solely by the authors and in no way supported by Cephalon. Lynn Webster, MD, is on Cephalon's speaker's bureau.

Publication History

  1. Issue published online: 5 JUN 2003
  2. Article first published online: 5 JUN 2003

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Keywords:

  • . Sedation;
  • Opioids;
  • Modafinil;
  • Fatigue

ABSTRACT

Study Objective. The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.

Design. A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS).

Setting. Outpatient, private practice.

Patients. Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain.

Results. A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment.

Conclusion. The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.

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