Relationships Among Hippocampal Volumetry, Proton Magnetic Resonance Spectroscopy, and Verbal Memory in Temporal Lobe Epilepsy
Article first published online: 12 JAN 2002
Volume 42, Issue 11, pages 1403–1407, November 2001
How to Cite
Sawrie, S. M., Martin, R. C., Knowlton, R., Faught, E., Gilliam, F. and Kuzniecky, R. (2001), Relationships Among Hippocampal Volumetry, Proton Magnetic Resonance Spectroscopy, and Verbal Memory in Temporal Lobe Epilepsy. Epilepsia, 42: 1403–1407. doi: 10.1046/j.1528-1157.2001.018301.x
- Issue published online: 12 JAN 2002
- Article first published online: 12 JAN 2002
- Revision accepted July 10, 2001.
- Temporal lobe epilepsy;
- Epilepsy surgery;
- Proton magnetic resonance spectroscopy;
Summary: Purpose: To examine the relationship between hippocampal volumes, 1H magnetic resonance spectroscopy (MRS)-identified hippocampal metabolic function, and verbal memory in patients with unilateral mesial temporal lobe epilepsy (MTLE).
Methods: Hippocampal volumes, 1H MRS-derived hippocampal creatine to N-acetylaspartate (Cr/NAA), and verbal memory assessment were obtained preoperatively in 22 patients (six right, 16 left) with EEG-defined unilateral MTLE.
Results: Left hippocampal volume correlated significantly with left hippocampal Cr/NAA (r = −0.549, p < 0.01), whereas right volume correlated significantly with right Cr/NAA (r = −0.478, p < 0.05). Verbal memory correlated significantly with left hippocampal Cr/NAA (r = −0.594, p < 0.01), but not with left hippocampal volume or right hippocampal measures.
Conclusions: Hippocampal volumes and 1H MRS-derived metabolite ratios are statistically related, but share only a small percentage of variance, suggesting separate but related pathophysiologic processes. Left hippocampal Cr/NAA appears to be more sensitive to verbal memory function than volumes.