A Proposed Diagnostic Scheme for People with Epileptic Seizures and with Epilepsy: Report of the ILAE Task Force on Classification and Terminology

Authors


Address correspondence and reprint requests to Dr. J. Engel, Jr., at Department of Neurology, Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, U.S.A. E-mail: engel@ucla.edu

The International League Against Epilepsy (ILAE) made a major contribution when it established standardized classifications and terminology for epileptic seizures and syndromes. This provided a universal vocabulary that not only facilitated communication among clinicians, but also established a taxonomic foundation for performing quantitative clinical and basic research on epilepsy. Much, however, has changed since the adoption of the currently used Classification of Epileptic Seizures in 1981 (1) and the Classification of Epilepsies and Epileptic Syndromes in 1989 (2). Consequently, the Executive Committee of the ILAE, which took office in July 1997, agreed that review and revision of the current classification system would be a priority for this Executive term.

A Task Force on Classification and Terminology was appointed, which divided itself into four working groups concerned with Descriptive Terminology for Ictal Events; Seizures; Syndromes and Diseases; and Impairment. During the course of several meetings and vigorous e-mail discussions, the Task Force agreed that it would not be possible to replace the current international classifications with similar revised and updated classifications that would be universally accepted and meet all the clinical and research needs such a formal organizational system would be expected to provide. Rather, the Task Force is proposing a diagnostic scheme that makes use of standardized terminology and concepts to describe individual patients (Table 1). Within this diagnostic scheme, a variety of approaches to classification are possible, and some are presented here by way of example only. The Task Force views the development of specific classifications as a continuing work in progress. Flexible and dynamic classifications will be revised periodically based not only on rapidly emerging new information, but also on the resolution of problems that will inevitably be identified through use. At this point, the proposal does include several definitive changes in concepts and terminology (Table 2), and classifications are presented as examples of what could be devised in the future.

Table 1.  Proposed diagnostic scheme for people with epileptic seizures and with epilepsy
Epileptic seizures and epilepsy syndromes are to be described and categorized according to a system that uses standardized terminology, and that is sufficiently flexible to take into account the following practical and dynamic aspects of epilepsy diagnosis:
 1. Some patients cannot be given a recognized syndromic diagnosis.
 2. Seizure types and syndromes change as new information is obtained.
 3. Complete and detailed descriptions of ictal phenomenology are not always necessary.
 4. Multiple classification schemes can, and should, be designed for specific purposes (e.g., communication and teaching; therapeutic trials; epidemiologic investigations; selection of surgical candidates; basic research; genetic characterizations).
This diagnostic scheme is divided into five parts, or Axes, organized to facilitate a logical clinical approach to the development of hypotheses necessary to determine the diagnostic studies and therapeutic strategies to be undertaken in individual patients:
Axis 1: Ictal phenomenology, from the Glossary of Descriptive Ictal Terminology, can be used to describe ictal events with any degree of detail needed.
Axis 2: Seizure type, from the List of Epileptic Seizures. Localization within the brain and precipitating stimuli for reflex seizures should be specified when appropriate.
Axis 3: Syndrome, from the List of Epilepsy Syndromes, with the understanding that a syndromic diagnosis may not always be possible.
Axis 4: Etiology, from a Classification of Diseases Frequently Associated with Epileptic Seizures or Epilepsy Syndromes when possible, genetic defects, or specific pathologic substrates for symptomatic focal epilepsies.
Axis 5: Impairment, this optional, but often useful, additional diagnostic parameter can be derived from an impairment classification adapted from the WHO ICIDH-2.
Table 2.  Definitions of key terms
Epileptic seizure type: An ictal event believed to represent a unique pathophysiologic mechanism and anatomic substrate. This is a diagnostic entity with etiologic, therapeutic, and prognostic implications. (new concept)
Epilepsy syndrome: A complex of signs and symptoms that define a unique epilepsy condition. This must involve more than just the seizure type: thus frontal lobe seizures per se, for instance, do not constitute a syndrome. (changed concept)
Epileptic disease: A pathologic condition with a single specific, well-defined etiology. Thus progressive myoclonus epilepsy is a syndrome, but Unverricht–Lundborg is a disease. (new concept)
Epileptic encephalopathy: A condition in which the epileptiform abnormalities themselves are believed to contribute to the progressive disturbance in cerebral function. (new concept)
Benign epilepsy syndrome: A syndrome characterized by epileptic seizures that are easily treated, or require no treatment, and remit without sequelae. (clarified concept)
Reflex epilepsy syndrome: A syndrome in which all epileptic seizures are precipitated by sensory stimuli. Reflex seizures that occur in focal and generalized epilepsy syndromes that also are associated with spontaneous seizures are listed as seizure types. Isolated reflex seizures also can occur in situations that do not necessarily require a diagnosis of epilepsy. Seizures precipitated by other special circumstances, such as fever or alcohol withdrawal, are not reflex seizures. (changed concept)
Focal seizures and syndromes: Replaces the terms partial seizures and localization-related syndromes. (changed terms)
Simple and complex partial epileptic seizures: These terms are no longer recommended, nor will they be replaced. Ictal impairment of consciousness will be described when appropriate for individual seizures, but will not be used to classify specific seizure types. (new concept)
Idiopathic epilepsy syndrome: A syndrome that is only epilepsy, with no underlying structural brain lesion or other neurologic signs or symptoms. These are presumed to be genetic and are usually age dependent. (unchanged term)
Symptomatic epilepsy syndrome: A syndrome in which the epileptic seizures are the result of one or more identifiable structural lesions of the brain. (unchanged term)
Probably symptomatic epilepsy syndrome: Synonymous with, but preferred to, the term cryptogenic, used to define syndromes that are believed to be symptomatic, but no etiology has been identified. (new term)

RATIONALE FOR THE PROPOSAL

Although each new ILAE classification has represented considerable effort on the part of acknowledged experts from many different countries, they have always met with a certain degree of resistance from the international epileptology community. This is because, in part, a rigid classification shapes the manner in which future generations of clinical and basic neuroscientists think about epilepsy and epileptic phenomena, thereby influencing (perhaps unduly) clinical practice and research. For instance, in the current Classification of Epileptic Seizures, the division of partial seizures into “simple” and “complex” inappropriately created the impression that impairment of consciousness had certain mechanistic implications related to limbic system involvement. Confusion, and at times vociferous objections, resulted in part from the fact that the 1970 International Classification of Epileptic Seizures had used the term “complex partial seizures” synonymously with “temporal lobe seizures”(3). Over the past two decades, detailed investigations of the anatomic substrates of ictal semiology, based largely on work carried out in epilepsy surgery centers, have strongly suggested that fundamental mechanisms of certain limbic seizures are different from those of neocortical seizures, and that both can be associated with impairment of consciousness or not. Consequently, the designation of partial seizures as “simple,” or “complex,” has in the process lost meaningful precision. Indeed, the 1981 Classification of Epileptic Seizures was purposely based purely on ictal phenomenology and associated EEG findings rather than anatomic substrates and pathophysiologic mechanisms, because insufficient information was available at the time to permit the authors to do otherwise. It is the belief of the Task Force that adequate evidence now exists to permit creation of a list of seizure types that represent diagnostic entities, as opposed to phenomenologic descriptions, based on known or presumed common anatomy and pathophysiology. Such diagnostic entities would, like syndromes, have etiologic, therapeutic, and prognostic implications, and could be used to supplement syndromic diagnoses, or stand alone when syndromic diagnoses cannot be made.

The 1981 Classification of Epileptic Seizures also has been criticized because it is not purely semiologic; post hoc etiologic information and EEG data are often required to use it properly, and the dichotomy of “partial” versus “generalized” belies a need to avoid anatomic implications. The Task Force believes that a purely descriptive phenomenologic approach to defining ictal semiology has definite clinical value, and the new diagnostic scheme proposed here includes a modification of a previously proposed classification of ictal phenomenology (4), as an option that can be used in detail where appropriate.

Similarly, the previous dichotomous classifications based on concepts of “partial” or “localization related” versus “generalized” abnormalities created the false impression that epileptic seizures, or epilepsy syndromes, were due to either localized disturbances in one hemisphere or disturbances involving the entire brain. A variety of conditions between focal and generalized epileptogenic dysfunctions include diffuse hemispheric abnormalities, multifocal abnormalities, and bilaterally symmetrical localized abnormalities. Although concepts of partial and generalized epileptogenicity have value, perhaps more with respect to ictal events than to syndromes, it is neither appropriate nor useful to attempt to contain all seizures and syndromes within one or the other of these categorizations.

The term partial itself has come under criticism because it implies part of a seizure, or part of a syndrome, rather than a seizure or syndrome that begins in part of one hemisphere. For this reason, the 1989 Classification of Epilepsies and Epileptic Syndromes replaced the term partial with “localization-related.” This latter terminology has been cumbersome and is not consistently used. The Task Force is now proposing that the terms partial and localization-related be replaced with the older term “focal,” which remains in common use. It must be strongly emphasized, however, that the term focal does not mean that the epileptogenic region is a small, well-delineated focus of neuronal pathology; focal seizures, as well as focal syndromes, are almost always due to diffuse, and at times widespread, areas of cerebral dysfunction.

Another change in terminology evident in this document is the omission of the words “convulsion” and “convulsive” in the list of epileptic seizure types and epilepsy syndromes. The Task Force thought that these are nonspecific lay terms, and at times improperly used. Consequently it was agreed to be consistent, not only in descriptive ictal terminology, but also in naming epileptic seizure types and syndromes, to avoid these terms. For instance, the Task Force is proposing that the term “febrile convulsions” be replaced by “febrile seizures.”

There also has been dissatisfaction with the terms “idiopathic” and “cryptogenic.” Problems with the former have resulted from misunderstanding of the correct definition of idiopathic, which means a disorder unto itself, sui generis, and not etiology unknown. Problems with the latter have been due to an imprecision in definition; cryptogenic is usually used to designate conditions that are not idiopathic, or are presumed to be symptomatic, when the etiology has not been determined, but it also is used by some for conditions in which it is not known whether they are idiopathic or symptomatic. The Task Force has been unable to find an acceptable alternative to the term idiopathic, which, when used correctly, confers a useful taxonomic concept. The terms “benign” and “genetic” were discarded because not all idiopathic epilepsies are necessarily benign, and not all genetic epileptic conditions (e.g., the progressive myoclonus epilepsies) are idiopathic. Although the term “essential” also is used in medicine to convey the same meaning, the Task Force believes that most epileptologists have now learned to use the term idiopathic correctly, and that there is value in maintaining continuity. Consequently, it is recommended that the terms idiopathic and symptomatic be retained, but that the term cryptogenic, although still acceptable, be replaced by the more precise term “probably symptomatic.” Therefore, some epilepsy syndromes are referred to as either idiopathic or symptomatic, but a dichotomous classification system that attempts to categorize all syndromes in this manner has been avoided.

Another important criticism of previous rigid syndromic classifications has been a failure to recognize the fact that some syndromes are well accepted, whereas others are controversial, or lack sufficient data. Formally recognizing a syndrome by including it in an official international classification may give it inappropriate legitimacy, whereas failing to recognize a syndrome in the official classification can discourage studies that are necessary to lead to its acceptance. Any official ILAE-sanctioned list of epilepsy syndromes must differentiate between universally accepted syndromes and those in development, and must also be sufficiently flexible to permit additions and deletions of syndromes as new information becomes available.

The rapidly moving field of genetics has contributed greatly in recent years to our understanding of many diseases, including some epileptic disorders, but the relationship between genetic disturbances and phenotypic expression remains complicated and poorly understood. Because a single, relatively well defined, idiopathic epilepsy syndrome can be due to more than one genetic abnormality, and different members of a family sharing a common genetic abnormality can have different epilepsy syndromes, it was considered premature to attempt to classify epilepsy syndromes, to any great extent, on the basis of specific genetic etiologies. There is no doubt, however, that in the near future, genetic classifications of certain epilepsy syndromes will become possible, and that these classifications will have considerable clinical value. It will be necessary for such classifications to include syndromes of families, in addition to syndromes of individuals, and indeed the Task Force has included three such conditions in the current recommended list of epilepsy syndromes (cf. Table 4): generalized epilepsy with febrile seizures plus, familial focal epilepsy with variable foci, and idiopathic generalized epilepsies with variable phenotypes. The first two of these are considered to be syndromes in development, and diagnosis would not be possible without evidence of multiple affected family members. The third is a new concept, which remains under discussion.

Table 4.  Epilepsy syndromes and related conditions
  • a

     Syndromes in development.

Benign familial neonatal seizures
Early myoclonic encephalopathy
Ohtahara syndrome
aMigrating partial seizures of infancy
West syndrome
Benign myoclonic epilepsy in infancy
Benign familial infantile seizures
Benign infantile seizures (nonfamilial)
Dravet's syndrome
HH syndrome
aMyoclonic status in nonprogressive encephalopathies
Benign childhood epilepsy with centrotemporal spikes
Early-onset benign childhood occipital epilepsy (Panayiotopoulos type)
Late-onset childhood occipital epilepsy (Gastaut type)
Epilepsy with myoclonic absences
Epilepsy with myoclonic–astatic seizures
Lennox–Gastaut syndrome
Landau–Kleffner syndrome (LKS)
Epilepsy with continuous spike-and-waves during slow-wave sleep (other than LKS)
Childhood absence epilepsy
Progressive myoclonus epilepsies
Idiopathic generalized epilepsies with variable phenotypes
 Juvenile absence epilepsy
 Juvenile myoclonic epilepsy
 Epilepsy with generalized tonic–clonic seizures only
Reflex epilepsies
 Idiopathic photosensitive occipital lobe epilepsy
 Other visual sensitive epilepsies
 Primary reading epilepsy
 Startle epilepsy
Autosomal dominant nocturnal frontal lobe epilepsy
Familial temporal lobe epilepsies
aGeneralized epilepsies with febrile seizures plus
aFamilial focal epilepsy with variable foci
Symptomatic (or probably symptomatic) focal epilepsies
 Limbic epilepsies
  Mesial temporal lobe epilepsy with hippocampal sclerosis
  Mesial temporal lobe epilepsy defined by specific etiologies
  Other types defined by location and etiology
 Neocortical epilepsies
  Rasmussen syndrome
  Other types defined by location and etiology
Conditions with epileptic seizures that do not require a diagnosis of epilepsy
 Benign neonatal seizures
 Febrile seizures
 Reflex seizures
 Alcohol-withdrawal seizures
 Drug or other chemically induced seizures
 Immediate and early posttraumatic seizures
 Single seizures or isolated clusters of seizures
 Rarely repeated seizures (oligoepilepsy)

DESCRIPTION OF THE PROPOSAL

The Task Force is asking the General Assembly to approve a diagnostic scheme, rather than a fixed classification, when it next meets in Buenos Aires in May 2001. This diagnostic scheme is intended to provide the basis for a standardized description of individual patients, and consists of five levels, or Axes (Table 1). The Axes are organized to facilitate a logical clinical approach to the development of hypotheses necessary to determine the diagnostic studies that should be performed, and the therapeutic strategies to be undertaken.

The diagnostic scheme described here will be made up of flexible and dynamic modules within which the Task Force will make periodic changes and updates as needed, with the approval of the Executive Committee. The Task Force is proposing that this diagnostic scheme include the development of flexible, rather than rigid, classifications, eliminating the need for the General Assembly, which meets only once every 2 years, to agree on every revision. Acceptance of this diagnostic scheme, therefore, does not exclude the creation of various classification systems for seizures and syndromes, or the continued use of some aspects of the current classification. The Task Force will be concerned with the construction of classification systems during the next Executive term, but it is anticipated that seizures and syndromes will not be organized into fixed dichotomous classifications, but rather categorized in various ways for various purposes.

Axis 1 consists of a description of the ictal semiology, using a standardized Glossary of Descriptive Terminology. The description of the ictal event, without reference to etiology, anatomy, or mechanisms, can be very brief or extremely detailed, as required for clinical or research purposes. Although detailed descriptions of the onset and evolution of localized ictal phenomena often are not necessary, they can be useful; for instance, in patients who are candidates for surgical treatment, or for research designed to elucidate the anatomic substrates or pathophysiologic mechanisms underlying specific clinical behaviors. Communication among clinicians, and among researchers, will be greatly enhanced by the establishment of standardized terminology for describing ictal semiology.

Axis 2 is the epileptic seizure type, or types, experienced by the patient, derived from a list of accepted seizure types that represent diagnostic entities with etiologic, therapeutic, and/or prognostic implications. Localization within the brain should be specified when this is appropriate, and in the case of reflex seizures, the specific stimulus also will be specified here. The Task Force has constructed a list of accepted epileptic seizure types, including forms of status epilepticus, and precipitating factors for reflex seizures (Table 3). Seizure types have been divided into self-limited seizures and continuous seizures, and further divided into generalized seizures and focal seizures, but it is anticipated that other approaches to organization, categorization, and classification of seizure types will be devised for specific purposes.

Table 3.  Epileptic seizure types and precipitating stimuli for reflex seizures
Self-limited seizure types
 Generalized seizures
  Tonic–clonic seizures (includes variations beginning with a   clonic or myoclonic phase)
  Clonic seizures
   Without tonic features
   With tonic features
  Typical absence seizures
  Atypical absence seizures
  Myoclonic absence seizures
  Tonic seizures
  Spasms
  Myoclonic seizures
  Eyelid myoclonia
   Without absences
   With absences
  Myoclonic atonic seizures
  Negative myoclonus
  Atonic seizures
  Reflex seizures in generalized epilepsy syndromes
 Focal seizures
  Focal sensory seizures
   With elementary sensory symptoms (e.g., occipital and parietal lobe seizures)
   With experiential sensory symptoms (e.g.,temporoparietooccipital junction seizures)
  Focal motor seizures
   With elementary clonic motor signs
   With asymmetric tonic motor seizures (e.g., supplementary motor seizures)
   With typical (temporal lobe) automatisms (e.g., mesial temporal lobe seizures)
   With hyperkinetic automatisms
   With focal negative myoclonus
   With inhibitory motor seizures
  Gelastic seizures
  Hemiclonic seizures
  Secondarily generalized seizures
  Reflex seizures in focal epilepsy syndromes
Continuous seizure types
 Generalized status epilepticus
  Generalized tonic–clonic status epilepticus
  Clonic status epilepticus
  Absence status epilepticus
  Tonic status epilepticus
  Myoclonic status epilepticus
 Focal status epilepticus
  Epilepsia partialis continua of Kojevnikov
  Aura continua
  Limbic status epilepticus (psychomotor status)
  Hemiconvulsive status with hemiparesis
Precipitating stimuli for reflex seizures
 Visual stimuli
  Flickering light: color to be specified when possible
  Patterns
  Other visual stimuli
 Thinking
 Music
 Eating
 Praxis
 Somatosensory
 Proprioceptive
 Reading
 Hot water
 Startle

Axis 3 is the syndromic diagnosis derived from a list of accepted epilepsy syndromes (Table 4), although it is understood that a syndromic diagnosis may not always be possible. The recommended list distinguishes between epilepsy syndromes and conditions with epileptic seizures that do not require a diagnosis of epilepsy, and also identifies which syndromes are still in development. It is important to stress that the list shown in Table 4 contains syndromes that are still under discussion, such as the new concept of Idiopathic generalized epilepsies with variable phenotypes, and the reflex epilepsies, and that the Task Force will continue to revise this list based on the results of further deliberations, input from the membership, and new information. As with epileptic seizures, it is anticipated that different approaches to organization, categorization, and classification of epilepsy syndromes will be created for specific purposes. One example of an approach to classification of epilepsy syndromes is shown in Table 5. Whereas this classification system may be easy for epileptologists to understand, a more simplified version will likely be constructed for teaching purposes, and used by primary care physicians, whereas more detailed, or completely different, classification systems might be necessary for epidemiologic studies, clinical drug trials, presurgical evaluation, basic research, and genetic characterizations.

Table 5.  An example of a classification of epilepsy syndromes
Groups of syndromesSpecific syndromes
  • a

     Syndromes in development.

Idiopathic focal epilepsies of infancy and childhoodBenign infantile seizures (nonfamilial)
 Benign childhood epilepsy with centrotemporal spikes
 Early-onset benign childhood occipital epilepsy (Panayiotopoulos type)
 Late-onset childhood occipital epilepsy (Gastaut type)
Familial (autosomal dominant) focal epilepsiesBenign familial neonatal seizures
 Benign familial infantile seizures
 Autosomal dominant nocturnal frontal lobe epilepsy
 Familial temporal lobe epilepsy
 Familial focal epilepsy with variable focia
Symptomatic (or probably symptomatic) focal epilepsiesLimbic epilepsies
  Mesial temporal lobe epilepsy with hippocampal sclerosis
  Mesial temporal lobe epilepsy defined by specific etiologies
  Other types defined by location and etiology
 Neocortical epilepsies
  Rasmussen syndrome
  Hemiconvulsion–hemiplegia syndrome
  Other types defined by location and etiology
  Migrating partial seizures of early infancya
Idiopathic generalized epilepsiesBenign myoclonic epilepsy in infancy
 Epilepsy with myoclonic astatic seizures
 Childhood absence epilepsy
 Epilepsy with myoclonic absences
 Idiopathic generalized epilepsies with variable phenotypes
  Juvenile absence epilepsy
  Juvenile myoclonic epilepsy
  Epilepsy with generalized tonic–clonic seizures only
 Generalized epilepsies with febrile seizures plusa
Reflex epilepsiesIdiopathic photosensitive occipital lobe epilepsy
 Other visual sensitive epilepsies
 Primary reading epilepsy
 Startle epilepsy
Epileptic encephalopathies (in which the epileptiform abnormalitiesEarly myoclonic encephalopathy
 may contribute to progressive dysfunction)Ohtahara syndrome
 West syndrome
 Dravet syndrome (previously known as severe myoclonic epilepsy in infancy)
 Myoclonic status in nonprogressive encephalopathiesa
 Lennox–Gastaut syndrome
 Landau–Kleffner syndrome
 Epilepsy with continuous spike–waves during slow-wave sleep
Progressive myoclonus epilepsiesSee specific diseases
Seizures not necessarily requiring a diagnosis of epilepsyBenign neonatal seizures
 Febrile seizures
 Reflex seizures
 Alcohol-withdrawal seizures
 Drug or other chemically induced seizures
 Immediate and early posttraumatic seizures
 Single seizures or isolated clusters of seizures
 Rarely repeated seizures (oligoepilepsy)

Axis 4 will specify etiology when this is known. The etiology could consist of a specific disease derived from a classification of diseases frequently associated with epileptic seizures or syndromes (Table 6), a genetic defect, or a specific pathologic substrate, for instance for the symptomatic focal epilepsies. The classification of diseases frequently associated with epileptic seizures shown in Table 6 is preliminary and will require considerable effort over the course of the next Executive Term to be made as comprehensive as possible.

Table 6.  An example of a classification of diseases frequently associated with epileptic seizures or syndromes
Groups of diseasesSpecific diseases
  1. MERRF, myoclonus epilepsy with ragged red fibers; DNET, dysembryoplastic neuroepithelial tumor; MELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms; CVI, cerebrovascular incident; HIV, human immunodeficiency virus.

Progressive myoclonic epilepsiesCeroid lipofuscinosis
 Sialidosis
 Lafora disease
 Unverricht–Lundborg disease
 Neuroaxonal dystrophy
 MERRF
 Dentatorubropallidoluysian atrophy
 Other
Neurocutaneous disordersTuberous sclerosis complex
 Neurofibromatosis
 Hypomelanosis of Ito
 Epidermal nevus syndrome
 Sturge–Weber syndrome
Malformations due to abnormal cortical developmentsIsolated lissencephaly sequence
 Miller–Dieker syndrome
 X-linked lissencephaly
 Subcortical band heterotopia
 Periventricular nodular heterotopia
 Focal heterotopia
 Hemimegalencephaly
 Bilateral perisylvian syndrome
 Unilateral polymicrogyria
 Schizencephalies
 Focal or multifocal cortical dysplasia
 Microdysgenesis
Other cerebral malformationsAicardi syndrome
 PEHO syndrome
 Acrocallosal syndrome
 Other
TumorsDNET
 Gangliocytoma
 Ganglioglioma
 Cavernous angiomas
 Astrocytomas
 Hypothalamic hamartoma (with gelastic seizures)
 Other
Chromosomal abnormalitiesPartial monosomy 4P or Wolf–Hirschhorn syndrome
 Trisomy 12p
 Inversion duplication 15 syndrome
 Ring 20 chromosome
 Other
Monogenic mendelian diseases with complex pathogeneticFragile X syndrome
 mechanismsAngelman syndrome
 Rett syndrome
 Other
Inherited metabolic disordersNonketotic hyperglycinemia
 d-Glyceric acidemia
 Propionic acidemia
 Sulphite-oxidase deficiency
 Fructose 1-6 diphosphatase deficiency
 Other organic acidurias
 Pyridoxine dependency
 Aminoacidopathies (maple syrup urine disease, phenylketonuria, other)
 Urea cycle disorders
 Disorders of carbohydrate metabolism
 Disorders of biotin metabolism
 Disorders of folic acid and B12 metabolism
 Glucose transport protein deficiency
 Menkes' disease
 Glycogen-storage disorders
 Krabbe disease
 Fumarase deficiency
 Peroxisomal disorders
 Sanfilippo syndrome
 Mitochondrial diseases (pyruvate dehydrogenase deficiency, respiratory chain defects, MELAS)
Prenatal or perinatal ischemic or anoxic lesions or cerebralPorencephaly
 infections causing nonprogressive encephalopathiesPeriventricular leukomalacia
 Microcephaly
 Cerebral calcifications and other lesions due to toxoplasmosis, CVI, HIV, etc.
Postnatal infectionsCysticercosis
 Herpes encephalitis
 Bacterial meningitis
 Other
Other postnatal factorsHead injury
 Alcohol and drug abuse
 Stroke
 Other
MiscellaneousCeliac disease (epilepsy with occipital calcifications and celiac disease)
 Northern epilepsy syndrome
 Coffin–Lowry syndrome
 Alzheimer's disease
 Huntington disease
 Alpers' disease

Axis 5 is an optional designation of the degree of impairment caused by the epileptic condition. Classification of impairment will be derived from the World Health Organization ICIDH-2 International Classification of Functioning and Disability (5), which is currently in preparation. Modification may be necessary for application to seizure disorders.

The most recent draft of the Glossary of Descriptive Terminology for Ictal Semiology (Axis 1), detailed descriptions of epileptic seizure types (Axis 2), and epileptic syndromes (Axis 3), and the current draft of the classification of the WHO ICIDH-2 (Axis 5) can be viewed on the ILAE classification website http://www.epilepsy.org/ctf. Although the proposal to be put to the ILAE General Assembly in May merely requests approval of the overall diagnostic scheme, with permission to continue to revise and update the details within each Axis in an ongoing, flexible manner, input from our membership now on these details, as well as on the overall scheme, will be most welcome. The Task Force would particularly like to invite comments on some of the more important remaining problems, including terms for describing ictal impairment of consciousness, the acceptance of idiopathic generalized epilepsies with variable phenotypes as a single syndrome, the inclusion of a category of epileptic encephalopathies, and the proposed categorization of reflex seizures and syndromes (see Classification Task Force Questionnaire). Comments for the Task Force can be directed to the chair by e-mail: engel@ucla.edu, mail, or fax (1-310-206-8461).

Acknowledgment: The work of the Task Force and the Classification website were supported in part by a generous grant from GlaxoSmithKline. The Axis concept was originally suggested by Dr. Jeffrey Nicholl.

NOTE

Members of the task force on classification and terminology include Jerome Engel, Jr., Los Angeles, California, U.S.A.: Chair; Warren Blume, London, Ontario, Canada: Chair, Working Group on Glossary of Descriptive Terminology; Peter Williamson, Lebanon, New Hampshire, U.S.A.: Chair, Working Group on Seizures; Natalio Fejerman, Buenos Aires, Argentina: Chair, Working Group on Syndromes and Diseases; Harry Meinardi, The Hague, Netherlands: Chair, Working Group on Impairment; Jean Aicardi, Paris, France; Frederick Andermann, Montreal, Quebec, Canada; Alexis Arzimanoglou, Paris, France; Giuliano Avanzini, Milan, Italy; Samuel Berkovic, Melbourne, Australia; Carol Camfield, Halifax, Nova Scotia, Canada; Bernardo Dalla Bernardina, Verona, Italy; Charlotte Dravet, Marseille, France; Francois Dubeau, Montreal, Quebec, Canada; Olivier Dulac, Paris, France; Orvar Eeg-Olofsson, Uppsala, Sweden; Robert Fraser, Seattle, Washington, U.S.A.; Renzo Guerrini, London, U.K.; Allen Hauser, New York, New York, U.S.A.; Matilde Leonardi, Geneva, Switzerland; Hans Lüders, Cleveland, Ohio, U.S.A.; Eli M. Mizrahi, Houston, Texas, U.S.A.; Claudio Munari (deceased), Milan, Italy; Jeffrey Noebels, Houston, Texas, U.S.A.; C.P. Panayiotopoulos, London, U.K.; Perrine Plouin, Paris, France; Marieke Reuvekamp-Thuss, Groningen, Netherlands; Masakazu Seino, Shizuoka, Japan; Arthur Sonnen (deceased), Breda, Netherlands; Carlo Alberto Tassinari, Bologna, Italy; Rupprecht Thorbecke, Bielefeld, Germany; David Treiman, New Brunswick, New Jersey, U.S.A.; Walter van Emde Boas, Heemstede, Netherlands; Federico Vigevano, Rome, Italy; Heinz-Gregor Wieser, Zürich, Switzerland; Peter Wolf, Bielefeld, Germany; and Benjamin Zifkin, Montreal, Quebec, Canada.

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