Increased Bone Turnover in Prepubertal, Pubertal, and Postpubertal Patients Receiving Carbamazepine
Article first published online: 11 DEC 2002
Volume 43, Issue 12, pages 1488–1492, December 2002
How to Cite
Verrotti, A., Greco, R., Latini, G., Morgese, G. and Chiarelli, F. (2002), Increased Bone Turnover in Prepubertal, Pubertal, and Postpubertal Patients Receiving Carbamazepine. Epilepsia, 43: 1488–1492. doi: 10.1046/j.1528-1157.2002.13002.x
- Issue published online: 11 DEC 2002
- Article first published online: 11 DEC 2002
- Accepted June 2, 2002.
- Bone metabolism;
- Epilepsy patients;
- Vitamin D;
- Pubertal stage
Summary: Purpose: To study the markers of bone turnover in epilepsy patients in the different stages of the pubertal growth before and after the beginning of carbamazepine (CBZ) monotherapy.
Methods: We have investigated bone turnover in 60 epilepsy patients treated with CBZ. They were stratified according to pubertal stage and compared with a control group of 60 sex- and age-matched healthy children.
Results: After 2 years of therapy, we found higher values of the serum markers of bone formation [bone alkaline phosphatase (bone ALP), osteocalcin (OC), carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP)], and of bone resorption [carboxy-terminal telopeptide of type I collagen (ICTP) and the urinary cross-linked N-telopeptides of type I collagen (NTX)] in patients than in control subjects, in presence of a normal vitamin D metabolism.
Conclusions: CBZ induces an increase of bone formation and of bone resorption that seems to be independent of the pubertal stage.