SEARCH

SEARCH BY CITATION

Keywords:

  • Suppression burst;
  • Lidocaine;
  • Hyponatremia;
  • Megalencephaly;
  • Sodium channel

Summary: We report an early infantile patient characterized by intractable hyponatremia, progressive megalencephaly, and epileptic seizures with an EEG pattern that alternated between interictal low-voltage background and ictal burst activity. Repeatedly all the abnormal findings improved in a lidocaine-dependent manner. Given the pharmacologic mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction.