• 1
    Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993;34:45368.
  • 2
    Charlier C, Singh NA, Ryan SG, et al. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family [see comments]. Nat Genet 1998;18:535.
  • 3
    Singh NA, Charlier C, Stauffer D, et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns [see comments]. Nat Genet 1998;18:259.
  • 4
    Fusco MD, Becchetti A, Patrignani A, et al. The nicotinic receptor beta2 subunit is mutant in nocturnal frontal lobe epilepsy. Nat Genet 2000;26:2756.
  • 5
    Steinlein OK, Mulley JC, Propping P, et al. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 1995;11:2013.
  • 6
    Wallace RH, Wang DW, Singh R, et al. Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 1998;19:36670.
  • 7
    Escayg A, MacDonald BT, Meisler MH, et al. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2. Nat Genet 2000;24:3435.
  • 8
    Baulac S, Huberfeld G, Gourfinkel-An I, et al. First genetic evidence of GABAA receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nat Genet 2001;28:468.
  • 9
    Wallace RH, Marini C, Petrou S, et al. Mutant GABAA receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet 2001;28:4952.
  • 10
    Greenberg DA, Delgado-Escueta AV, Widelitz H, et al. Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. Am J Med Genet 1988;31:18592.
  • 11
    Weissbecker KA, Durner M, Janz D, et al. Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6. Am J Med Genet 1991;38:326.
  • 12
    Durner M, Sander T, Greenberg DA, et al. Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients. Neurology 1991;41:16515.
  • 13
    Liu AW, Delgado-Escueta AV, Serratosa JM, et al. Juvenile myoclonic epilepsy locus in chromosome 6p21.2-p11:linkage to convulsions and electroencephalography trait. Am J Hum Genet 1995;57:36881.
  • 14
    Liu AW, Delgado-Escueta AV, Gee MN, et al. Juvenile myoclonic epilepsy in chromosome 6p12-p11: locus heterogeneity and recombinations. Am J Med Genet 1996;63:43846.DOI: 10.1002/(sici)1096-8628(19960614)63:3<438::aid-ajmg5>;2-r
  • 15
    Sander T, Bockenkamp B, Hildmann T, et al. Refined mapping of the epilepsy susceptibility locus EJM1 on chromosome 6. Neurology 1997;49:8427.
  • 16
    Durner M, Zhou G, Fu D, et al. Evidence for linkage of adolescent-onset idiopathic generalized epilepsies to chromosome 8-and genetic heterogeneity. Am J Hum Genet 1999;64:14119.
  • 17
    Durner M, Keddache MA, Tomasini L, et al. Genome scan of idiopathic generalized epilepsy: evidence for major susceptibility gene and modifying genes influencing the seizure type. Ann Neurol 2001;49:32835.DOI: 10.1002/ana.69.abs
  • 18
    Fong GC, Shah PU, Gee MN, et al. Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24. Am J Hum Genet 1998;63:111729.
  • 19
    Guipponi M, Rivier F, Vigevano F, et al. Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q. Hum Mol Genet 1997;6:4737.
  • 20
    Caraballo R, Pavek S, Lemainque A, et al. Linkage of benign familial infantile convulsions to chromosome 16p12-q12 suggests allelism to the infantile convulsions and choreoathetosis syndrome. Am J Hum Genet 2001;68:78894.
  • 21
    Szepetowski P, Rochette J, Berquin P, et al. Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16. Am J Hum Genet 1997;61:88998.
  • 22
    Malacarne M, Gennaro E, Madia F, et al. Benign familial infantile convulsions: mapping of a novel locus on chromosome 2q24 and evidence for genetic heterogeneity. Am J Hum Genet 2001;68:15216.
  • 23
    Zara F, Gennaro E, Stabile M, et al. Mapping of a locus for a familial autosomal recessive idiopathic myoclonic epilepsy of infancy to chromosome 16p13. Am J Hum Genet 2000;66:15527.
  • 24
    Plaster NM, Uyama E, Uchino M, et al. Genetic localization of the familial adult myoclonic epilepsy (FAME) gene to chromosome 8q24. Neurology 1999;53:11803.
  • 25
    Phillips HA, Scheffer IE, Crossland KM, et al. Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Am J Hum Genet 1998;63:110816.
  • 26
    Neubauer BA, Fiedler B, Himmelein B, et al. Centrotemporal spikes in families with rolandic epilepsy: linkage to chromosome 15q14. Neurology 1998;51:160812.
  • 27
    Xiong L, Labuda M, Li DS, et al. Mapping of a gene determining familial partial epilepsy with variable foci to chromosome 22q11-q12. Am J Hum Genet 1999;65:1698710.
  • 28
    Johnson EW, Dubovsky J, Rich SS, et al. Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest. Hum Mol Genet 1998;7:637.
  • 29
    Wallace RH, Berkovic SF, Howell RA, et al. Suggestion of a major gene for familial febrile convulsions mapping to 8q13-21. J Med Genet 1996;33:30812.
  • 30
    Nakayama J, Hamano K, Iwasaki N, et al. Significant evidence for linkage of febrile seizures to chromosome 5q14-q15. Hum Mol Genet 2000;9:8791.
  • 31
    Kugler SL, Stenroos ES, Mandelbaum DE, et al. Hereditary febrile seizures: phenotype and evidence for a chromosome 19p locus. Am J Med Genet 1998;79:35461.DOI: 10.1002/(sici)1096-8628(19981012)79:5<354::aid-ajmg5>;2-j
  • 32
    Ottman R, Risch N, Hauser WA, et al. Localization of a gene for partial epilepsy to chromosome 10q [see comments]. Nat Genet 1995;10:5660.
  • 33
    Poza JJ, Saenz A, Martinez-Gil A, et al. Autosomal dominant lateral temporal epilepsy: clinical and genetic study of a large Basque pedigree linked to chromosome 10q. Ann Neurol 1999;45:1828.
  • 34
    Michelucci R, Passarelli D, Pitzalis S, et al. Autosomal dominant partial epilepsy with auditory features: description of a new family. Epilepsia 2000;41:96770.
  • 35
    Winawer MR, Ottman R, Hauser WA, et al. Autosomal dominant partial epilepsy with auditory features: defining the phenotype. Neurology 2000;54:21736.
  • 36
    Mautner VF, Lindenau M, Gottesleben A, et al. Supporting evidence of a gene for partial epilepsy on 10q. Neurogenetics 2000;3:314.
  • 37
    Ottman R, Barker-Cummings C, et al. Genetics of autosomal dominant partial epilepsy with auditory features. In: BerkovicSF, GentonP, HirschE, et al., eds. Genetics of focal epilepsies: clinical aspects and molecular biology. London: John Libbey, 1999:95192.
  • 38
    Ottman R, Hauser WA, Stallone L. Semistructured interview for seizure classification: agreement with physicians' diagnoses. Epilepsia 1990;31:1105.
  • 39
    Ottman R, Lee JH, Hauser WA, et al. Reliability of seizure classification using a semistructured interview. Neurology 1993;43:252630.
  • 40
    Commission on Classification and Terminology, ILAE. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22:489501.
  • 41
    Commission on Classification and Terminology, ILAE. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:38999.
  • 42
    Ghosh S, Karanjawala ZE, Hauser ER, et al. Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers: FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group. Genome Res 1997;7:16578.
  • 43
    Reed PW, Davies JL, Copeman JB, et al. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nat Genet 1994;7:3905.
  • 44
    Goring HH, Terwilliger JD. Linkage analysis in the presence of errors, III: marker loci and their map as nuisance parameters. Am J Hum Genet 2000;66:1298309.
  • 45
    Kruglyak L, Daly MJ, Reeve-Daly MP, et al. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996;58:134763.
  • 46
    Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:2417.