• 1
    Freeman JM, Vining EPG, Pillas DJ, et al. The efficacy of the ketogenic diet–1998: a prospective evaluation of intervention in 150 children. Pediatrics 1998;102:135863.
  • 2
    Vining EPG, Freeman JM, Ballaban-Gil K, et al. A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 1998;55:14337.
  • 3
    Huttenlocher PR. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:53640.
  • 4
    Gilbert DL, Pyzik PL, Freeman JM. The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones. J Child Neurol 2000;15:78790.
  • 5
    Schwartz RM, Boyes S, Aynsley-Green A. Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol 1989;31:15260.
  • 6
    White HS, Patel S, Meldrum BS. Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent. Epilepsy Res 1992;12:21726.
  • 7
    Arafat ES, Hargrove JT, Maxon WS, et al. Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites. Am J Obstet Gynecol 1988;159:12039.
  • 8
    Williamson DH, Mellanby J. d-(−)-3-Hydroxybutyrate. In: Methods of enzymatic analysis, 2nd ed. New York: Academic Press, 1974:183639.
  • 9
    Doepner B, Thierfelder S, Hirche H, et al. 3-Hydroxybutyrate blocks the transient K+ outward current in myocardial mouse cells in a stereoselective fashion. J Physiol (Lond) 1997;500:8594. Retraction, J Physiol (Lond). 1998;508:956.
  • 10
    Keith HM. Factors influencing experimentally produced convulsions. Arch Neurol Psych 1933;29:14854.
  • 11
    Höld KM, Sirisoma NS, Ikeda T, et al. α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci USA 2000;97:382631.
  • 12
    Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 2000;54:32531.
  • 13
    Seymour KJ, Bluml S, Sutherling J, et al. Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet. MAGMA 1999;8:3342.
  • 14
    Pan JW, Rothman TL, Behar KL, et al. Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab 2000;20:15027.
  • 15
    Leino RL, Gerhart DZ, Duelli R, et al. Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 2001;38:51927.
  • 16
    Moore TJ, Armand PL, Sugden MC, et al. β-Hydroxybutyrate transport in rat brain: developmental and dietary modulations. Am J Physiol 1976;230:61930.
  • 17
    Herzberg GR, Gad M. Evidence that the cytosolic activity of 3-hydroxybutyrate dehydrogenase in chicken liver is l-3-hydroxyacid dehydrogenase. Biochim Biophys Acta 1984;802:6770.
  • 18
    Webber RM, Edmond J. Utilization of l-(+)-3-hydroxybutyrate, d-(−)-3-hydroxybutyrate, acetoacetate, and glucose for respiration and lipid synthesis in the 18-day-old rat. J Biol Chem 1977;252:52226.