Amygdala Kindling in Proechimys guyannensis Rat: An Animal Model of Resistance to Epilepsy
Article first published online: 6 FEB 2003
Volume 44, Issue 2, pages 165–170, February 2003
How to Cite
De Amorim Carvalho, R., Arida, R. and Cavalheiro, Esper A. (2003), Amygdala Kindling in Proechimys guyannensis Rat: An Animal Model of Resistance to Epilepsy. Epilepsia, 44: 165–170. doi: 10.1046/j.1528-1157.2003.32202.x
- Issue published online: 6 FEB 2003
- Article first published online: 6 FEB 2003
- Accepted September 23, 2002.
Summary: Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.
Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.
Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4–5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1–3 and 5 and longer afterdischarge duration in stages 1–4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.
Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species.