• 1
    McNamara J. Emerging insights into the genesis of epilepsy. Nature 1999;399: A1522.
  • 2
    Huang L, Cilio MR, Silveira CD, et al. Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study. Dev Brain Res 1999;118: 99107.
  • 3
    Mathern GW, Pretorius JK, Babb TL. Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures. J Neurosurg 1995;82: 2207.
  • 4
    Schmid R, Tandon P, Stafstrom C, et al. Effects of neonatal seizures on subsequent seizure-induced brain injury. Neurology 1999;53: 175461.
  • 5
    Vernadakis A, Woodbury DM. The developing animal as a model. Epilepsia 1969;10: 16378.
  • 6
    Traynelis SF, Dingledine R. Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol 1988;59: 25976.
  • 7
    Wada JA, Sato M, Corcoran ME. Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia 1974;15: 46578.
  • 8
    Meilleur SL, Carmant L, Psarropoulou C. Immature rat convulsions and long term effects on hippocampal cholinergic neurotransmission. Neuroreport 2000;11: 5214.
  • 9
    Acquas E, Wilson C, Fibiger H. Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty, habituation and fear. J Neurosci 1996;16: 308996.
  • 10
    Moor E, Schirm E, Jacso J, et al. Involvement of medial septal glutamate and GABAA receptors in behaviour-induced acetylcholine release in the hippocampus: a dual probe microdialysis study. Brain Res 1998;789: 18.
  • 11
    Gardner C, Webster R. Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. Eur J Pharmacol 1977;42: 24756.
  • 12
    Imperato A, Dazzi L, Carta G, et al. Rapid increase in basal acetylcholine release in the hippocampus of freely moving rats induced by withdrawal from long-term ethanol intoxication. Brain Res 1998;784: 34750.
  • 13
    Lapchak P, Araujo D, Quirion R, et al. Chronic estradiol treatment alters central cholinergic function in the female rat: effect on choline acetyltransferase activity, acetylcholine content, and nicotinic autoreceptor function. Brain Res 1990;525: 24955.
  • 14
    Aznavour N, Mechawar N, Descarries L. Comparative analysis of cholinergic innervation in the dorsal hippocampus of adult mouse and rat: a quantitative immunocytochemical study. Hipppocampus 2002;12: 20617.
  • 15
    Mechawar N, Cozzari C, Descarries L. Cholinergic innervation in adult rat cerebral cortex: a quantitative immunocytochemical description. J Comp Neurol 2000;428: 30518.
  • 16
    Umbriaco D, Watkins KC, Descarries L, et al. Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: an electron microscopic study in serial sections. J Comp Neurol 1994;348: 35173.
  • 17
    Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 2nd ed. Orlando, Fla.: 1986.
  • 18
    Gaskell S. Electrospray: principles and practice. J Mass Spectrom 1997;32: 67788.
  • 19
    Acevedo LY, Xu X, Zhang R, et al. Quantification of acetylcholine in cell culture systems by semi-micro high-performance liquid chromatography and electrospray ionization mass spectrometry. J Mass Spectrom 1996;31: 1399402.
  • 20
    Gruslin E, Descombes S, Psarropoulou C. Epileptiform activity generated by endogenous acetylcholine during blockade of GABAergic inhibition in immature and adult rat hippocampus. Brain Res 1999;835: 2907.
  • 21
    Psarropoulou C, Beaucher J, Harnois C. Comparison of the effects of MI and M2 muscarinic receptor activation in the absence of GABAergic inhibition in immature rat hippocampal CA3 area. Dev Brain Res 1998;107: 28590.
  • 22
    Psarropoulou C, Dallaire F. Activation of muscarinic receptors during blockade of GABAA-mediated inhibition induces synchronous epileptiform activity in immature rat hippocampus. Neuroscience 1998;82: 106777.
  • 23
    Haberer L, Pollack G. Central nervous system uptake kinetics of pentylenetetrazol in the developing rat. Biopharm Drug Dispos 1991;12: 5971.
  • 24
    Esplin D, Woodbury D. The fate and excretion of 14C-labelled pentylenetetrazol in the rat with comments on analytical methods. J Pharmacol Exp Ther 1957;118: 129.
  • 25
    Vohland H, Koransky W. Effect of hexachlorocyclohexane on metabolism and excretion of pentazol (Metrazol) in the rat. Naunyn Schmiedebergs Arch Pharmacol 1972;273: 99108.
  • 26
    Halonen T, Pitkanen A, Partanen J, et al. Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol. Comp Biochem Physiol 1992;101C: 215.
  • 27
    Nehlig A, Pereira de Vasconcelos A. The model of pentylenetetrazolinduced status epilepticus in the immature rat: short- and long-term effects. Epilepsy Res 1996;26: 93103.
  • 28
    Velisek L, Kubova H, Pohl M, et al. Pentylenetetrazol-induced seizures in rats: an ontogenetic study. Naunyn Schmiedebergs Arch Pharmacol 1992;346: 58891.
  • 29
    Weller A, Mostofsky DI. Ontogenetic development and pentylenetetrazol seizure thresholds in rats. Physiol Behav 1995;57: 62931.
  • 30
    Holmes GL, Sarkisian M, Ben-Ari Y, et al. Mossy fiber sprouting after recurrent seizures during early development in rats. J Comp Neurol 1999;404: 53753.
  • 31
    Carmant L, Liu Z, Werner S, et al. Effect of kainic-acid induced status epilepticus on inositol-triphosphate and seizure-induced brain damage in mature and immature animals. Dev Brain Res 1995;89: 6772.
  • 32
    Anderson A, Hrachovy R, Swann J. Increased susceptibility to tetanus toxin-induced seizures in immature rats. Epilepsy Res 1997;26: 43342.
  • 33
    Rouse ST, Marino MJ, Potter LT, et al. Muscarinic receptor subtypes involved in hippocampal circuits. Life Sci 1999;64: 5019.
  • 34
    Lal H, Mann PA Jr, Shearman GT, et al. Effect of acute and chronic pentylenetetrazol treatment on benzodiazepine and cholinergic receptor binding in rat brain. Eur J Pharmacol 1981;75: 1159.
  • 35
    Lothman EW, Bertram EH III, Stringer JL. Functional anatomy of hippocampal seizures. Prog Neurobiol 1991;37: 182.
  • 36
    Papatheodoropoulos C, Kostopoulos G. Spontaneous GABA(A)-dependent synchronous periodic activity in adult rat ventral hippocampal slices. Neurosci Lett 2002;319: 1720.
  • 37
    Turski L, Ikonomidou C, Turski WA, et al. Review: cholinergic mechanisms and epileptogenesis: the seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse 1989;3: 15471.
  • 38
    Lee C, Hrachovy R, Smith K, et al. Tetanus toxin-induced seizures in infant rats and their effects on hippocamapal excitability in adulthood. Brain Res 1995;677: 97109.
  • 39
    Psarropoulou C, Matsokis N, Angelatou F, et al. Pentylenetetrazol-induced seizures decrease GABA-mediated recurrent inhibition and enhance adenosine-mediated depression. Epilepsia 1994;35: 129.
  • 40
    Imperato A, Dazzi L, Obinu MC, et al. Inhibition of hippocampal acetylcholine release by benzodiazepines: antagonism by flumazenil. Eur J Pharmacol 1993;238: 1357.
  • 41
    Roussinov K, Lazarova M. On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions. Acta Physiol Pharmacol Bulg 1977;3: 2836.
  • 42
    Mangan P, Rempe D, Lothman E. Changes in inhibitory neurotransmission in the CA1 region and dentate gyrus in a chronic model of temporal lobe epilepsy. J Neurophysiol 1995;74: 82940.
  • 43
    Zhao D, Leung LS, Boon F, et al. Persistent physiological effects caused by a single pentylenetetrazol induced seizure in neonatal rats. Dev Brain Res 1994;80: 1908.
  • 44
    Holmes GL, Gairsa JL, Chevassus-Au-Louis N, et al. Consequences of neonatal seizures in the rat: morphological and behavioral effects. Ann Neurol 1998;44: 84557.
  • 45
    Holtzman DM, Lowenstein DH. Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy. J Neurosci 1995;15: 706270.
  • 46
    Somani SM, Babu SR, Arneric SP, et al. Effect of cholinesterase inhibitor and exercise on choline acetyltransferase and acetylcholinesterase activities in rat brain regions. Pharmacol Biochem Behav 1991;39: 33743.
  • 47
    Parent JM, Lowenstein DH. Mossy fiber reorganization in the epileptic hippocampus. Curr Opin Neurol 1997;10: 1039.
  • 48
    Lallement G, Carpentier P, Collet A, et al. Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures. Neurotoxicology 1992;13: 55767.
  • 49
    Mingo NS, Cottrell GA, Mendonca A, et al. Amygdala-kindled and electroconvulsive seizures alter hippocampal expression of the M1 and M3 muscarinic cholinergic receptor genes. Brain Res 1998;810: 915.
  • 50
    Vosu H, Wise RA. Cholinergic seizure kindling in the rat: comparison of caudate, amygdala and hippocampus. Behav Biol 1975;13: 4915.
  • 51
    Kawasaki K, Eigyo M, Ikeda M, et al. A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer. Prog Neuropsychopharmacol Biol Psychiatry 1996;20: 141325.
  • 52
    Cassel JC, Kelche C, Will BE. Susceptibility to pentylenetetrazol-induced and audiogenic seizures in rats with selective fimbria-fornix lesions and intrahippocampal septal grafts. Exp Neurol 1987;97: 56476.
  • 53
    Bagri A, Di Scala G, Sandner G. Myoclonic and tonic seizures elicited by microinjection of cholinergic drugs into the inferior colliculus. Therapie 1999;54: 58994.
  • 54
    Cain DP, Desborough KA, McKitrick DJ. Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: evidence for the summation of excitatory mechanisms in kindling. Exp Neurol 1988;100: 17987.
  • 55
    Huang LT, Yang SN, Liou CW, et al. Pentylenetetrazol-induced recurrent seizures in rat pups: time course on spatial learning and long-term effects. Epilepsia 2002;43: 56773.