Restricted Frontomesial Epileptogenic Focus Generating Dyskinetic Behavior and Laughter
Article first published online: 9 JUN 2003
Volume 44, Issue 6, pages 859–863, June 2003
How to Cite
Chassagnon, S., Minotti, L., Kremer, S., Verceuil, L., Hoffmann, D., Benabid, A. L. and Kahane, P. (2003), Restricted Frontomesial Epileptogenic Focus Generating Dyskinetic Behavior and Laughter. Epilepsia, 44: 859–863. doi: 10.1046/j.1528-1157.2003.60802.x
- Issue published online: 9 JUN 2003
- Article first published online: 9 JUN 2003
- Brain mapping;
- cingulate gyrus;
- cingulate motor areas;
- electric stimulation;
- frontal lobe epilepsy;
- magnetic resonance imaging;
- radiofrequency lesion;
- sup plementary motor area
Summary: Purpose: Substantial data are missing about the anatomic location of frontal regions supporting gelastic seizures.
Methods: We report the results of stereo-electro-encep halographic recordings performed over several distinct functional premotor and executive fields in a patient whose seizures were characterized by dyskinetic behavior and ictal laughter, in the absence of cerebral MRI abnormalities.
Results: The epileptogenic zone was circumscribed in the anterior and ventral part of the supplementary motor area and the underlying dorsal cingulate cortex. There were no or little spreading to cortical neighboring areas. The patient is seizure-free (follow-up of 27 months) after a stereotactic electric radiofrequency lesion of the epileptogenic focus.
Conclusion: The present data suggest that pericingulate premotor areas are involved in the triggering of the motor component of laughter. In this case, the coexistence of paroxysmal dyskinesias during laughter might reflect the involvement of specific compartment(s) of the basal ganglia.