• 1
    Reinscheid RK, Notacker HP, Bourson A, et al. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor et al. Science 1995;270:7924.
  • 2
    Meunier JC, Mollereau C, Toll L, et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995;377:5325.
  • 3
    Mollereau C, Parmentier M, Mailleux P, et al. ORL1, a novel member of the opioid receptor family: cloning, functional expression and localization. FEBS Lett 1994;341:338.
  • 4
    Calò G, Guerrini R, Bigoni R, et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol 2000;129:126183.
  • 5
    Neal CR Jr, Mansour A, Reinscheid R, et al. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding. J Comp Neurol 1999;412:563605.
  • 6
    Neal CR Jr, Mansour A, Reinscheid R, et al. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol 1999;406:50347.
  • 7
    Bregola G, Candeletti S, Romualdi P, et al. Limbic seizures increase pronociceptin mRNA levels in the thalamic reticular nucleus. Neuroreport 1999;10:5416.
  • 8
    Yu TP, Xie CW. Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms. J Neurophysiol 1998;80:127784.
  • 9
    Koster A, Montkowski A, Schulz S, et al. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci U S A 1999;96:104449.
  • 10
    Janumpalli S, Butler LS, MacMillan LB, et al. A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. J Neurosci 1998;18:20048.
  • 11
    Mulle C, Sailer A, Perez-Otano I, et al. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature1998;392:6015.