The research on which this publication is based was performed pursuant to National Institutes of Health Contract N01-AG-12102 and research Grant R01-AG12765. Additional support was provided by a pilot grant from the Hartford Foundation. The content of this publication does not necessarily reflect the views or policies of the U.S. Department of Health and Human Services.
Cross-Linked Fibrin Degradation Products (D-Dimer), Plasma Cytokines, and Cognitive Decline in Community-Dwelling Elderly Persons
Article first published online: 23 SEP 2003
Journal of the American Geriatrics Society
Volume 51, Issue 10, pages 1374–1381, October 2003
How to Cite
Wilson, C. J., Cohen, H. J. and Pieper, C. F. (2003), Cross-Linked Fibrin Degradation Products (D-Dimer), Plasma Cytokines, and Cognitive Decline in Community-Dwelling Elderly Persons. Journal of the American Geriatrics Society, 51: 1374–1381. doi: 10.1046/j.1532-5415.2003.51454.x
- Issue published online: 23 SEP 2003
- Article first published online: 23 SEP 2003
Objectives: To investigate the effect of coagulation and inflammatory pathway activation on future cognitive decline in older persons.
Design: Prospective cohort study.
Setting: Rural and urban communities in North Carolina.
Participants: Community-dwelling older people enrolled in the Duke Established Populations for Epidemiologic Studies of the Elderly in 1986.
Measurements: In 1992, blood was drawn for assay of D-dimer (1,723 subjects), Interleukin-6 (1,726 subjects), and other cytokines (1,551 subjects). Cognitive and functional assessments were performed in 1986, 1989, 1992, and 1996. Cognition was measured using the Short Portable Mental Status Questionnaire.
Results: Cognitive decline over a 4-year period was significantly correlated (P<.001) with D-dimer, age, race, and physical performance status as measured using the Rosow-Breslau and Nagi instruments. After controlling for demographics, functional status, and comorbidities, D-dimer remained predictive of cognitive decline. Proinflammatory cytokines were not associated with current cognitive status in cross-sectional analyses or with incident cognitive decline in prospective analyses.
Conclusion: In a large sample of community-dwelling elders, higher levels of D-dimer were predictive of cognitive decline over a 4-year period. No clinically significant associations were found between age-related peripheral cytokine dysregulation and cognition.