Peter D. Issitt, F.I.M.L.S., M.I. Biol., M.R.C.Path., Director of Laboratories and Associate Professor in Research Surgery, The Paul I. Hoxworth Blood Center of the University of Cincinnati, 3231 Burnet Avenue, Cincinnati, Ohio 45267.
Anti-Rh39—A “New” Specificity Rh System Antibody
Version of Record online: 25 MAR 2003
Volume 19, Issue 4, pages 389–397, July-August 1979
How to Cite
Issitt, P. D., Pavone, B. G. and Shapiro, M. (1979), Anti-Rh39—A “New” Specificity Rh System Antibody. Transfusion, 19: 389–397. doi: 10.1046/j.1537-2995.1979.19479250175.x
- Issue online: 25 MAR 2003
- Version of Record online: 25 MAR 2003
- Received for publication June 26, 1978; accepted August 5, 1978
Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C-negative individuals and ostensibly resembled anti-C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a “normal” Rh phenotype and on D—/D— and Dc-/Dc- samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti-Rh39, has a different specificity from those that define the antigens C, Ce(rh1), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto-anti-Rh39 and alio-anti-C, in terms of the immune response, is discussed.