David C. Stump, MD, Department of Medicine, University of Iowa College of Medicine, University of Iowa Hospitals and Clinics.
Hydroxyethyl starch accentuates von Willebrand's disease
Version of Record online: 5 MAR 2003
Volume 25, Issue 3, pages 235–237, May-June 1985
How to Cite
Strauss, R. G., Stump, D. C. and Henriksen, R. A. (1985), Hydroxyethyl starch accentuates von Willebrand's disease. Transfusion, 25: 235–237. doi: 10.1046/j.1537-2995.1985.25385219904.x
- Issue online: 5 MAR 2003
- Version of Record online: 5 MAR 2003
- Submitted for publication August 6, 1984; revision received October 3, 1984, and accepted October 15, 1984
A healthy man with previously undiagnosed, mild von Willebrand's disease received one 1 of 6 percent hydroxyethyl starch solution intravenously. Following infusion, the bleeding time lengthened, platelet adhesion decreased, and the partial thromboplastin time was prolonged in association with decreased plasma levels of factor VIII coagulant activity, factor VIII-related antigen, and factor VIII ristocetin cofactor. Abnormalities persisted for days, but overt bleeding did not occur. Care should be taken to screen and possibly reject prospective granulocyte donors with positive personal or family bleeding histories. Caution should be used when administering hydroxyethyl starch as a colloidal plasma volume expanding agent to patients with underlying hemostatic defects.