S. Breanndan Moore, MB, FRCPI, Head, Section of Transfusion Medicine, Mayo Clinic and Mayo Foundation; Professor of Laboratory Medicine, Mayo Medical School.
Posttransfusion purpura: the therapeutic value of PlA1-negative platelets
Article first published online: 5 MAR 2003
Volume 30, Issue 5, pages 433–435, June 1990
How to Cite
Brecher, M.E., Moore, S.B. and Letendre, L. (1990), Posttransfusion purpura: the therapeutic value of PlA1-negative platelets. Transfusion, 30: 433–435. doi: 10.1046/j.1537-2995.1990.30590296377.x
- Issue published online: 5 MAR 2003
- Article first published online: 5 MAR 2003
- Received for publication May 5, 1989; revision received September 19, 1989, and accepted November 17, 1989
A case of PlA1-associated posttransfusion purpura (PTP) is reported, in which a previously sensitized patient developed life-threatening thrombocytopenia, purpura, hematuria, and bronchial bleeding. The patient was transfused with PlA1-negative single-donor apheresis platelets (from four different donors) on four occasions. The first transfusion resulted in a 1-hour posttransfusion increment of 57 times 109 per L. The use of two additional PlA1-negative apheresis platelets provided support for a tracheostomy. Bronchial bleeding leading to respiratory arrest was controlled with a fourth transfusion. All PlA1-negative platelet transfusions resulted in transient increases in the patient's platelet count. This is the first reported case of repeated, transiently effective transfusion of PlA1-negative platelets demonstrated during the acute phase of thrombocytopenia.