Virginia W. Hare, MT(ASCP)SBB, Assistant Director, Technical Services, Specialized Services and Tests, American Red Cross Blood Services-Atlanta Region, Atlanta, Georgia.
Autologous and allogeneic red cell survival studies in the presence of autoanti-AnWj
Article first published online: 28 FEB 2003
Volume 33, Issue 10, pages 845–847, October 1993
How to Cite
Whitsett, C.F., Hare, V.W., Oxendine, S.M. and Pierce, J.A. (1993), Autologous and allogeneic red cell survival studies in the presence of autoanti-AnWj. Transfusion, 33: 845–847. doi: 10.1046/j.1537-2995.1993.331094054624.x
- Issue published online: 28 FEB 2003
- Article first published online: 28 FEB 2003
- Received for publication July 14, 1992; revision received March 4, 1993, and accepted March 18, 1993.
Chromium survival studies were performed with AnWj-positive allogeneic blood in a patient with autoanti-AnWj. 99mTc-labeled autologous RBCs that had depressed AnWj expression had normal survival (77% [94.7% 51Cr equivalent]) at 24 hours, whereas 51Cr-labeled allogeneic AnWj-positive cells had 76 percent survival at 24 hours and 55 percent survival at 7 days. These studies suggest that the specificity of the autoantibody may have implications for transfusion therapy when the development of such autoantibodies is associated with decreased antigen expression on the patient's cells.