Valerie Thiers, Research Engineer, Hybridotest; and Research Engineer, INSERM U75 CHU Necker.
Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels
Article first published online: 28 FEB 2003
Volume 33, Issue 8, pages 629–633, August 1993
How to Cite
Romeo, R., Thiers, V., Driss, F., Berthelot, P., Nalpas, B. and Brechot, C. (1993), Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels. Transfusion, 33: 629–633. doi: 10.1046/j.1537-2995.1993.33893342742.x
- Issue published online: 28 FEB 2003
- Article first published online: 28 FEB 2003
- Received for publication November 25, 1992; revision received February 18, 1993, and accepted February 19, 1993.
The pattern of hepatitis C virus (HCV) viremia in blood donors who are positive for antibody to HCV (anti-HCV) according to the level of transaminase activity is unclear. A polymerase chain reaction-based HCV RNA detection method was used to study two clearly defined groups of anti-HCV-positive blood donors with repeatedly normal (n = 27) and elevated (n = 17) alanine aminotransferase (ALT) levels. HCV RNA was detected in only 4 of 27 blood donors with normal ALT values and 15 of 17 with elevated ALT values. These results indicate that anti-HCV-positive blood donors with normal ALT levels constitute a heterogeneous group, as HCV viremia is detectable in only a small proportion of cases. Polymerase chain reaction should be useful in the surveillance of anti-HCV-positive blood donors with normal ALT levels, by identifying those who might benefit from further investigation and treatment.