Secretaria de Estado da Saúde, Hospital Brigadeiro, Department of Pathology and Laboratory Medicine, Hematology-Oncology Service, São Paulo, Brazil.
Transfusion-associated graft-versus-host disease in immunocompetent patients: report of a fatal case associated with transfusion of blood from a second-degree relative, and a survey of predisposing factors
Article first published online: 28 FEB 2003
Volume 33, Issue 9, pages 742–750, September 1993
How to Cite
Petz, L.D., Calhoun, L., Yam, P., Cecka, M., Schiller, G., Faitlowicz, A.R., Herron, R., Sayah, D., Wallace, R.B. and Belldegrun, A. (1993), Transfusion-associated graft-versus-host disease in immunocompetent patients: report of a fatal case associated with transfusion of blood from a second-degree relative, and a survey of predisposing factors. Transfusion, 33: 742–750. doi: 10.1046/j.1537-2995.1993.33994025025.x
- Issue published online: 28 FEB 2003
- Article first published online: 28 FEB 2003
- Received tor publication February 2, 1993; revision received and accepted April 14, 1993.
A patient without evident immune deficiency who received a transfusion of blood from a second-degree family member developed fatal transfusion- associated graft-versus-host disease (TA-GVHD). The donor was homozygous for an HLA haplotype for which the recipient was heterozygous (one-way HLA match). All 39 reported cases of TA-GVHD in immunocompetent patients were reviewed to ascertain the predisposing factors and to define the indications for irradiating blood for this population. HLA typing was described in 15 cases; in 13, including seven related and six unrelated donors, a one-way HLA match was present. Thirty-one (79%) of the 39 cases were reported from Japan (and 196 other cases are cited in the Japanese literature), but a one-way HLA match among unrelated donors at HLA-A, -B, -DR loci is only approximately two to four times more likely in Japanese persons than in whites. Fresh blood (< 96 hours old) was used in 29 (94%) of the 31 cases reported from Japan and in 33 (87%) of 38 cases overall (in one case, the age of the blood used was not reported). Thus, factors that appear to predispose to TA-GVHD in immunocompetent patients are a one- way HLA match, fresh blood, and, possibly, Japanese ancestry. Irradiating cellular blood components from all blood relatives of transfusion recipients will not completely eliminate the risk of TA- GVHD.