Red cell alloimmunization after a bone allograft

Authors

  • Robert F. Cheek,

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    • 2

      Robert F. Cheek, MD, Baxter Fellow in Clinical Pathology, Department of Pathology, Massachusetts General Hospital.

  • James V. Harmon,

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    • 3James V. Harmon, MD, Assistant Director, Blood Transfusion Service, Massachusetts General Hospital; current address: Fellow, Department of Surgery, University of Minnesota, Minneapolis, MN.
  • Christopher P. Stowell MD, PhD

    Director, Corresponding author
      1Blood Transfusion Service, Massachusetts General Hospital, 34 Fruit Street, GRJ 212, Boston, MA 02114.
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1Blood Transfusion Service, Massachusetts General Hospital, 34 Fruit Street, GRJ 212, Boston, MA 02114.

Abstract

BACKGROUND: Alloimmunization to blood group antigens other than ABH after bone allografting is uncommon. To date, examples of alloimmunization to blood group antigens other than ABH have been limited to the Rh system. CASE REPORT: A 20-year-old woman received an allogeneic bone graft following resection of an osteosarcoma. The patient had received no blood components and denied any pregnancies. Alloimmunization was detected and alloantibodies were identified by standard serologic techniques. Fourteen months after the bone graft, anti-Fya and anti-Jkb were identified in her serum. CONCLUSION: Alloimmunization to blood group antigens other than ABO and Rh may follow bone allografting.

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