Edward L. Murphy, MD, MPH, Associate Professor in Residence, Departments of Laboratory Medicine and Epidemiology/Biostatistics, University of California San Francisco, San Francisco, CA.
Psychological distress in blood donors notified of HTLV-I/II infection. Retrovirus Epidemiology Donor Study
Article first published online: 9 OCT 2008
Volume 38, Issue 11-12, pages 1056–1062, November-December 1998
How to Cite
Guiltinan, A.M., Murphy, E.L., Horton, J. A., Nass, C.C., McEntire, R.L. and Watanabe, K. (1998), Psychological distress in blood donors notified of HTLV-I/II infection. Retrovirus Epidemiology Donor Study. Transfusion, 38: 1056–1062. doi: 10.1046/j.1537-2995.1998.38111299056317.x
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
- Received for publiaction October 20, 1997; revision received May 11, 1998, and accepted May 18, 1998.
BACKGROUND: Blood donations in the United States have been screened for antibody to human T-cell lymphotropic virus types I and II (HTLV-I/II) since November 1988. Although clinically diagnosed illness associated with HTLV-I/II remains relatively uncommon, blood donors notified of HTLV infection frequently report negative psychological and social effects following notification. STUDY DESIGN AND METHODS: To assess psychological outcomes, the General Well-Being Scale, a standardized 18- item questionnaire, was administered to 464 HTLV-I/II-positive donors and 91 sex partners at five blood centers in the United States following notification of HTLV-I/II infection. The questionnaire was also given to 735 HTLV-I/II-negative donors. RESULTS: Scores for donors seropositive for HTLV-I and HTLV-II showed significantly more psychological distress than did scores for seronegative donors (p < 0.0005) or a large national sample (p < 0.05). Both HTLV-I (p = 0.02) and HTLV-II (p = 0.01) seropositivity remained significant predictors of lower overall well-being scores after analysis controlling for race, age, gender, education, income, donation type, time since notification, self-reported health status, and intravenous drug use. Variables that predicted higher overall scores were negative HTLV status, older age, higher income, better health, fewer sick days, and fewer work limitations due to health problems. CONCLUSION: Increased psychological distress may be related to notification of HTLV infection among blood donors in the United States.