Address reprint requests to: Girolamo Sirchia, MD, FRCP Edin, Milano Cord Blood Bank, Centro Trasfusionale e di Immunologia dei Trapianti, IRCCS Ospedale Maggiore, via Francesco Sforza 35, 20122 Milan, Italy; e-mail: email@example.com.
Cost of umbilical cord blood units released for transplantation
Article first published online: 25 APR 2002
Volume 39, Issue 6, pages 645–650, June 1999
How to Cite
Sirchia, G., Rebulla, P., Tibaldi, S. and Lecchi, L. (1999), Cost of umbilical cord blood units released for transplantation. Transfusion, 39: 645–650. doi: 10.1046/j.1537-2995.1999.39060645.x
Supported in part by grants from Progetto Sangue of Istituto Superiore di Sanità, Fondazione CARIPLO, Banca Nazionale delle Comunicazioni, and Associazione Italiana per la Ricerca sul Cancro.
- Issue published online: 25 APR 2002
- Article first published online: 25 APR 2002
- Received: 09 June 1998; Revised: 05 1998; Accepted: 26 1998
- GRACE = Gruppo per la Raccolta e Amplificazione delle Cellule Ematopoietiche [Group for the Collection and Expansion of Hematopoietic Cells];
- HPC(s) = hematopoietic progenitor cell(s);
- MCBB = Milano (Italy) Cord Blood Bank;
- UCB = umbilical cord blood.
BACKGROUND: A large number of institutions have started programs banking umbilical cord blood (UCB) for allogeneic unrelated-donor and related-donor transplantation. However, limited information is available on the financial issues surrounding these activities.
STUDY DESIGN AND METHODS: The aim of this study was to determine the fee per UCB unit released for transplantation that would allow cost recovery after 10 years. Three organizational models were considered suitable to provide units for five UCB transplants per 1 million population per year, a figure that would translate into an annual need for 280 units in Italy. Models A, B, and C included, respectively, seven networked banks, each with an inventory of 1,500 units; two networked banks, each with an inventory of 5,000 units; and one bank with an inventory of 10,000 units. It was estimated that it would take 3 years to develop the cryopreserved inventory and that approximately 3 percent of the inventory could be released and replaced each year during the 7-year interval between the fourth and tenth years of activity. The data on the costs of labor, reagents and diagnostics, disposables, depreciation and maintenance, laboratory tests, and overhead, as well as the operational data used in the analysis were collected at the Milano Cord Blood Bank in 1996.
RESULTS: Fees of US $15,061, $12,666, and $11,602 per unit released during the fourth through the tenth years of activity allow full cost recovery (principle and interest) under Models A, B, and C, respectively.
CONCLUSION: Although UCB procurement costs compare favorably with those of other hematopoietic cell sources, these results and the current fee of US $15,300 used in some institutions show that UCB is an expensive resource. Therefore, judicious planning of banking programs with high quality standards is necessary to prevent economic losses. The advantages of lower fees associated with the centralized banking approach of Model C should be balanced with the more flexible collection offered by Model A.