Acute intravascular hemolysis after transfusion of a chimeric RBC unit
Article first published online: 26 SEP 2003
Volume 43, Issue 10, pages 1449–1451, October 2003
How to Cite
Pruss, A., Heymann, G. A., Hell, A., Kalus, U. J., Krausch, D., Dörner, T., Kiesewetter, H. H. and Salama, A. (2003), Acute intravascular hemolysis after transfusion of a chimeric RBC unit. Transfusion, 43: 1449–1451. doi: 10.1046/j.1537-2995.2003.00515.x
- Issue published online: 26 SEP 2003
- Article first published online: 26 SEP 2003
- Received for publication March 3, 2003; revision received April 14, 2003, and accepted May 23, 2003.
BACKGROUND: Natural blood cell chimerism rarely occurs in humans. The case of a patient who developed transfusion reaction due to the transfusion of chimeric RBCs is reported.
CASE REPORT: A 61-year-old male patient with blood group O received two units of packed and O-grouped RBCs after elective kidney surgery. Immediately after blood transfusion, the patient developed a hemolytic transfusion attack. The serologic re-examination revealed only a mixed-field pattern of agglutination of RBCs in one of the two transfused units. The donor of this unit was an apparently healthy 24-year-old male with a twin sister. Both of them showed an identical mixture of roughly 95 percent group O and 5 percent group B RBCs by gel agglutination technology and flow cytometry. The results were also confirmed by ABO blood group genotyping.
CONCLUSIONS: This is the first report of a hemolytic transfusion reaction related to the transfusion of chimeric RBCs.