Pain in Femoral Arteriography
A double-blind, randomized, clinical study comparing safety and efficacy of the iso-osmolar iodixanol 270 mgI/ml and the low-osmolar iomeprol 300 mgI/ml in 9 European centers
Article first published online: 18 NOV 2003
Volume 44, Issue 6, pages 590–596, November 2003
How to Cite
Manke, C., Marcus, C., Page, A., Puey, J., Batakis, O. and Fog, A. (2003), Pain in Femoral Arteriography. Acta Radiologica, 44: 590–596. doi: 10.1046/j.1600-0455.2003.00129.x
- Issue published online: 18 NOV 2003
- Article first published online: 18 NOV 2003
- Accepted for publication 28 July 2003.
- Contrast media;
- digital subtraction;
- controlled clinical trial
Purpose: To compare the injection-associated pain and heat sensation after administration of the iso-osmolar contrast medium (IOCM) iodixanol (Visipaque™ 270 mg I/ml) and the low osmolar contrast medium (LOCM) iomeprol (Iomeron™ 300 mg I/ml) in femoral arteriography.
Material and Methods: 352 patients received iodixanol or iomeprol in a prospective, double-blind, randomized, parallel-group clinical trial. The first injection during femoral arteriography (DSA with automated stepping) was standardized. Injection-associated pain and heat sensation, efficacy and safety up to 72 h were evaluated.
Results: The iodixanol group reported significant less injection-associated pain than the iomeprol group after the first injection (7.4% vs. 17.6%; p = 0.007), and after all injections (11% vs. 19.4%; p = 0.045). Iodixanol caused less heat sensation after the first injection (p = 0.007) and after all injections (p = 0.029). Heat sensations in the iodixanol group were less intense after all injections (p < 0.0001). No difference was found between the groups regarding the frequency of patients having adverse reactions (5.1% vs. 4%).
Conclusion: The IOCM iodixanol caused significantly less frequent injection-associated pain and heat sensation than the LOCM iomeprol during femoral arteriography.