Preemptive Renal Transplantation: Why Not?
Article first published online: 28 OCT 2003
American Journal of Transplantation
Volume 3, Issue 11, pages 1336–1340, November 2003
How to Cite
Mange, K. C. and Weir, M. R. (2003), Preemptive Renal Transplantation: Why Not?. American Journal of Transplantation, 3: 1336–1340. doi: 10.1046/j.1600-6143.2003.00232.X
- Issue published online: 28 OCT 2003
- Article first published online: 28 OCT 2003
- Received 21 April 2003, revised 12 June and accepted for publication 12 June 2003
- renal transplantation
Dialysis has been the long-established initial choice of treatment for persons with end-stage renal disease. Transplantation before dialysis, or preemptive renal transplantation (PRT), has been controversial because of the paucity of clinical evidence that has clarified the benefits vs. risks of this approach. However, several recent observational analyses indicate that PRT is the optimal strategy to benefit patients requiring renal replacement therapy. This current review will discuss the advantages that are associated with PRT, and will summarize studies that have investigated the impact of the timing of transplantation on outcomes. We will also discuss the utility of PRT from various perspectives, and describe the challenges ahead in expanding the opportunity of PRT for more patients.