Financial support: Supported by the Ministry of Health, Labour and Welfare, Japan.
PCBs, Hexachlorobenzene and DDE are not Associated with Recurrent Miscarriage
Version of Record online: 5 NOV 2003
American Journal of Reproductive Immunology
Volume 50, Issue 6, pages 485–489, December 2003
How to Cite
Sugiura-Ogasawara, M., Ozaki, Y., Sonta, S.-i., Makino, T. and Suzumori, K. (2003), PCBs, Hexachlorobenzene and DDE are not Associated with Recurrent Miscarriage. American Journal of Reproductive Immunology, 50: 485–489. doi: 10.1046/j.8755-8920.2003.00106.x
- Issue online: 5 NOV 2003
- Version of Record online: 5 NOV 2003
- Submitted December 24, 2002; revised April 21, 2003; accepted June 11, 2003.
- 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene;
- endocrine disrupters;
- polychlorinated biphenyl;
- recurrent miscarriage
Problem: A case-control study was designed to evaluate any associations between high exposure to polychlorinated biphenyls (PCB), hexachlorobenzene (HCB) and the 1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (DDE) and recurrent miscarriage and immunoendocrine abnormalities.
Methods of study: A total of 18 kinds of co-planer PCBs, HCB, DDE, natural killer cell (NK) activity, antiphospholipid antibodies, antinuclear antibody, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3–11) consecutive first-trimester miscarriages and 30 healthy women with no history of live birth and infertility.
Results: There were no differences in mean ± S.D. values in serum samples for PCBs, HCB and DDE between patients and controls. Hypothyroidism, hyperprolactinemia, luteal phase defects, NK cell activity and the presence of autoantibodies were also not associated with levels of any of the compounds in the patients.
Conclusion: PCBs, HCB and DDE are not associated with miscarriage and immunoendocrine abnormalities in patients with a history of recurrent miscarriage.