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γ/δT-cell Subsets, NKG2A Expression and Apoptosis of Vδ2+ T cells in Pregnant Women with or without Risk of Premature Pregnancy Termination

Authors


Address reprint requests to Julia Szekeres-Bartho, Department of Medical Microbiology and Immunology, Pecs University, Medical School, H-7624 Pecs, Szigeti ut 12, Hungary.
E-mail: szjuli@main.pote.hu

Abstract

Problem:  Potentially cytotoxic Vδ2+ T lymphocytes recognize human leukocyte antigen-E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ/δ T-cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination.

Method of Study:  Peripheral Vδ2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry.

Results:  The percentage of viable Vδ2+ T cells was higher, that of Vδ1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ Vδ2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy.

Conclusions:  These data suggest the involvement of γ/δ T lymphocytes in the pathogenesis of premature pregnancy termination.

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