Abnormal First Trimester Serum Interleukin 18 Levels are Associated with a Poor Outcome in Women with a History of Recurrent Miscarriage
Article first published online: 27 JAN 2004
American Journal of Reproductive Immunology
Volume 51, Issue 2, pages 156–159, February 2004
How to Cite
Wilson, R., Moor, J., Jenkins, C., Miller, H., Walker, J. J., McLean, M. A., Norman, J. and McInnes, I. B. (2004), Abnormal First Trimester Serum Interleukin 18 Levels are Associated with a Poor Outcome in Women with a History of Recurrent Miscarriage. American Journal of Reproductive Immunology, 51: 156–159. doi: 10.1046/j.8755-8920.2003.00126.x
- Issue published online: 27 JAN 2004
- Article first published online: 27 JAN 2004
- Submitted May 19, 2003; revised July 29, 2003; accepted August 1, 2003.
- recurrent miscarriage;
- Th1-type immune response
Problem: How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines.
Method of study: Levels of interferon (IFN)-γ, interleukin (IL)-4, IL-12 and IL-18 were measured in serum from 205 pregnant women of whom 115 pregnant women had a history of recurrent miscarriage.
Results: Compared with healthy pregnant women those who miscarried had increased serum levels of the Th1-associated cytokines IFN-γ, IL-12 and IL-18.
Conclusions: Increased levels of IL-18 appeared to be critical in early pregnancy and were able to discriminate between pregnancies that continued and those that end in miscarriage.