Shall We properly Re-examine the Status of Allogeneic Lymphocyte Therapy for Recurrent early Pregnancy Failure?


  • David A. Clark

    1. Departments of Medicine, Molecular Medicine and Pathology, Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada and McMaster University Medical Center, Hamilton, Ontario, Canada
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Address reprint requests to David A. Clark, McMaster University Medical Center, 1200 Main St, West Rm. 3V39, Hamilton, Ontario, Canada L8N 3Z5.


Problem:  How to evaluate immunological therapy advocated for recurrent spontaneous abortion and implantation failure. I was invited to comment on the opinion article of Chaouat (AJRI December 2003).

Methods:  A critical examination of key beliefs and application of the principles of evidence and logic utilizing current data.

Results and Conclusions:  Although rationale has no bearing on efficacy of proposed treatments and is not sufficient justification for routine practice, insufficient attention to data concerning patient selection, insufficient attention to treatment methodology, and lack of full disclosure in some clinical trials needs to be corrected. A more systematic collection of follow-up data is needed.