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Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants
Article first published online: 30 DEC 2003
DOI: 10.1053/jhep.2000.8626
Copyright © 2000 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Perrillo, R., Schiff, E., Yoshida, E., Statler, A., Hirsch, K., Wright, T., Gutfreund, K., Lamy, P. and Murray, A. (2000), Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants. Hepatology, 32: 129–134. doi: 10.1053/jhep.2000.8626
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Accepted: 20 APR 2000
- Manuscript Received: 17 FEB 2000
Funded by
- A.M.'s current address is Roche Molecular Systems, Pleasanton, CA
REFERENCES
- 1, , , , , , , et al. A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med 1998; 339:61–68.MEDLINE
- 2, , , , , , , et al. A placebo controlled study of lamivudine and interferon alpha 2b in patients with chronic hepatitis B who previously failed interferon therapy [Abstract]. Hepatology 1998; 28(Suppl):388A.
- 3, , , , , , , et al. Lamivudine and intron A combination treatment in patients with chronic hepatitis B infection [Abstract]. J Hepatol 1998; 28:43.
- 4, , , , , , , et al. Multicenter study of lamivudine therapy for hepatitis B after liver transplantation. Hepatology 1999; 29:1581–1586.MEDLINE
- 5, , , , , , , et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Hepatology 1998; 27:1670–1677.MEDLINE
- 6, , , , , , , et al. Clinical significance of YMDD mutant hepatitis B virus (HBV) in a large cohort of lamivudine-treated hepatitis B patients [Abstract]. Hepatology 1998; 28(Suppl):319A.
- 7, , , , , , , et al. Two year lamivudine therapy in chronic hepatitis B infection: results of a placebo-controlled multicentre study in Asia [Abstract]. Gastroenterology 1998; 114(Suppl):1289.
- 8, , , , , , , et al. Three year lamivudine therapy in chronic HBV [Abstract]. J Hepatol 1999; 30:59.
- 9, , , , , , , et al. Hepatitis B virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet 1997; 349:20–22.MEDLINE
- 10, , , , , , , et al. Post liver transplant allograft reinfection with a lamivudine-resistant strain of hepatitis B virus: long term follow up. Can J Gastroenterol 1998; 12:125–129.MEDLINE
- 11, , , , , . Management and outcome of lamivudine (LAM) resistant hepatitis B virus (HBV) infection after liver transplantation [Abstract ]. Hepatology 1997; 26(Suppl):260A.
- 12, , , , . Famciclovir treatment in lamivudine resistant chronic hepatitis B [Abstract]. J Hepatol 1998; 28:113.
- 13, , , , . Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro. Hepatology 1998; 28:1669–1673.MEDLINE
- 14, , , , . Human hepatitis B virus DNA polymerases which contain mutations arising during famciclovir treatment remain sensitive to adefovir [Abstract]. Hepatology 1998; 28(Suppl):491A.
- 15, , , , , , , et al. A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection. J Viral Hepatitis 1999; 6:387–395.Direct Link:
- 16, , , , , , , et al. Loss of serum HBV DNA and HBeAg and seroconversion following short-term (12 weeks) adefovir dipivoxil therapy in chronic hepatitis B: two placebo-controlled phase II studies [Abstract]. Hepatology 1998; 28(Suppl):317A.
- 17, , , , , , , et al. Genotypic succession of mutations of the HBV polymerase associated with lamivudine resistance in chronic hepatitis B and liver transplantation [Abstract]. Hepatology 1998; 28(Suppl):487A.
- 18, , , , , , , et al. Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. J Hepatol 1997; 26:1148–1153.MEDLINE
- 19, , , , , , , et al. Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation. Hepatology 1999; 30:244–256.MEDLINE
- 20, , , , , , , et al. Susceptibility of lamivudine resistant hepatitis B virus to other antivirals: adefovir and lobucavir [Abstract]. Hepatology 1998; 28(Suppl):165A.
- 21
- 22, , , , , , , et al. Cyclosporin A modulates the course of woodchuck hepatitis virus infection and induces chronicity. J Immunol 1991; 146:3138–3144.MEDLINE
- 23, , , , , , , et al. Adefovir Dipivoxil (ADV) 60 mg and 120 mg in combination regimens for PI-naïve patients [Abstract]. 7th Conference on Retroviruses and Opportunistic Infections 2000;528.
- 24, , , , , , , et al. Efficacy and safety of adefovir dipivoxil with antiretroviral therapy. A randomized, controlled trial. JAMA 1999; 282:2305–2312.MEDLINE

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