• 1
    Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, Elliston K, et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992; 267:1499815004.MEDLINE
  • 2
    Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 1994; 14:15211528.MEDLINE
  • 3
    Thornalley PJ. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Cell Mol Biol (Noisy-le-grand) 1998; 44:10131023.
  • 4
    Schmidt AM, Yan SD, Wautier JL, Stern D. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res 1999; 84:489497.MEDLINE
  • 5
    Brett J, Schmidt AM, Yan SD, Zou YS, Weidman E, Pinsky D, Nowygrod R, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol 1993; 143:16991712.MEDLINE
  • 6
    Schmidt AM, Yan SD, Yan SF, Stern DM. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 2000; 20:23.
  • 7
    Bierhaus A, Ritz E, Nawroth PP. Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease. Nephrol Dial Transplant 1996; 5:8790.
  • 8
    Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 1996; 382:685691.MEDLINE
  • 9
    Sousa MM, Yan SD, Stern D, Saraiva MJ. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor κB (NF-κB) activation. Lab Invest 2000; 80:11011110.MEDLINE
  • 10
    Hori O, Yan SD, Ogawa S, Kuwabara K, Matsumoto M, Stern D, Schmidt AM. The receptor for advanced glycation end-products has a central role in mediating the effects of advanced glycation end-products on the development of vascular disease in diabetes mellitus. Nephrol Dial Transplant 1996; 11:1316.MEDLINE
  • 11
    Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, Illmer T, Luther T, et al. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997; 46:14811490.MEDLINE
  • 12
    Mohamed AK, Bierhaus A, Schiekofer S, Tritschler H, Ziegler R, Nawroth PP. The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 1999; 10:157167.MEDLINE
  • 13
    Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen JX, Nagashima M, et al. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem 1995; 270:2575225761.MEDLINE
  • 14
    Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999; 274:1991919924.MEDLINE
  • 15
    Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through RAGE activation. J Biol Chem 2000; 275:4009640105.MEDLINE
  • 16
    Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000; 405:354360.MEDLINE
  • 17
    Cataldegirmen G, Hoffman M, Kislinger T, Schmidt AM, Stern D. Blockade of receptor for AGE (RAGE): a novel strategy results in enhanced regeneration and marked survival benefit after massive hepatectomy in mice [Abstract]. Hepatology 2000; 32:325A.
  • 18
    Gressner AM. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int Suppl 1996; 54:S39S45.MEDLINE
  • 19
    Burt AD. Pathobiology of hepatic stellate cells. J Gastroenterol 1999; 34:299304.MEDLINE
  • 20
    Friedman SL. The virtuosity of hepatic stellate cells. Gastroenterology 1999; 117:12441246.MEDLINE
  • 21
    Brenner DA, Waterboer T, Choi SK, Lindquist JN, Stefanovic B, Burchardt E, Yamauchi M, et al. New aspects of hepatic fibrosis. J Hepatol 2000; 32:3238.MEDLINE
  • 22
    Gressner AM. The cell biology of liver fibrogenesis—an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998; 292:447452.MEDLINE
  • 23
    Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275:22472250.MEDLINE
  • 24
    Gong W, Pecci A, Roth S, Lahme B, Beato M, Gressner AM. Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand. Hepatology 1998; 28:492502.MEDLINE
  • 25
    Roth-Eichhorn S, Kuhl K, Gressner AM. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Hepatology 1998; 28:15881596.MEDLINE
  • 26
    Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 2000; 31:10941106.MEDLINE
  • 27
    Giron MD, Vargas AM, Suarez MD, Salto R. Sequencing of two alternatively spliced mRNAs corresponding to the extracellular domain of the rat receptor for advanced glycosylation end products (RAGE). Biochem Biophys Res Commun 1998; 251:230234.MEDLINE
  • 28
    Seglen PO: Preparation of isolated rat liver cells. In: PrescotDM, ed. Methods in Cell Biology. New York: Academic Press, 1987:2983.
  • 29
    de Leeuw AM, McCarthy SP, Geerts A, Knook DL. Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 1984; 4:392403.MEDLINE
  • 30
    Schäfer S, Zerbe O, Gressner AM. The synthesis of proteoglycans in fat-storing cells of rat liver. Hepatology 1987; 7:680687.MEDLINE
  • 31
    Gressner AM, Zerbe O. Kupffer cell–mediated induction of synthesis and secretion of proteoglycans by rat liver fat-storing cells in culture. J Hepatol 1987; 5:299310.MEDLINE
  • 32
    Knook DL, Blansjaar N, Sleyster EC. Isolation and characterization of Kupffer and endothelial cells from the rat liver. Exp Cell Res 1977; 109:317329.MEDLINE
  • 33
    Zerbe O, Gressner AM. Proliferation of fat-storing cells is stimulated by secretions of Kupffer cells from normal and injured liver. Exp Mol Pathol 1988; 49:87101.MEDLINE
  • 34
    Weiskirchen R, Gressner AM. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). Biochem Biophys Res Commun 2000; 274:655663.MEDLINE
  • 35
    Renard C, Chappey O, Wautier MP, Nagashima M, Lundh E, Morser J, Zhao L, et al. Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats. Mol Pharmacol 1997; 52:5462.MEDLINE
  • 36
    Renard C, Chappey O, Wautier MP, Nagashima M, Morser J, Scherrmann JM, Wautier JL. The human and rat recombinant receptors for advanced glycation end products have a high degree of homology but different pharmacokinetic properties in rats. J Pharmacol Exp Ther 1999; 290:14581466.MEDLINE
  • 37
    Sambrook J, Fritsch EF, Maniatis T: Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
  • 38
    Fehrenbach H, Kasper M, Tschernig T, Shearman MS, Schuh D, Müller M. Receptor for advanced glycation end products (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. Cell Mol Biol (Noisy-Le-Grand) 1998; 44:11471157.
  • 39
    Schulze E, Witt M, Kasper M, Lowik CW, Funk RH. Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8. Histochem Cell Biol 1999; 111:6169.MEDLINE
  • 40
    Kasper M, Koslowski R, Luther T, Schuh D, Müller M, Wenzel KW. Immunohistochemical evidence for loss of ICAM-1 by alveolar epithelial cells in pulmonary fibrosis. Histochem Cell Biol 1995; 104:397405.MEDLINE
  • 41
    Weiskirchen R, Siemeister G, Hartl M, Bister K. Sequence and expression of a glyceraldehyde-3-phosphate dehydrogenase-encoding gene from quail embryo fibroblasts. Gene 1993; 128:269272.MEDLINE
  • 42
    Itoh H, Koyata H, Takahara T, Watanabe A, Hiraga K. Prostacyclin administration suppresses the increase in hepatic levels of COL1A(I) and glyceraldehyde-3-phosphate dehydrogenase mRNAs in the rat treated with carbon tetrachloride. Biochem Biophys Res Commun 1992; 185:981986.MEDLINE
  • 43
    Alexander-Bridges M, Dugast I, Ercolani L, Kong XF, Giere L, Nasrin N. Multiple insulin-responsive elements regulate transcription of the GAPDH gene. Adv Enzyme Regul 1992; 32:149159.MEDLINE
  • 44
    Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995; 270:2748927494.MEDLINE
  • 45
    Pricci F, Leto G, Amadio L, Iacobini C, Romeo G, Cordone S, Gradini R, et al. Role of galactin-3 as a receptor for advanced glycosylation end products. Kidney Int 2000; 58:S31S39.
  • 46
    Yang Z, Makita Z, Horii Y, Brunelle S, Cerami A, Sehajpal P, Suthanthiran M, et al. Two novel rat liver membrane proteins that bind advanced glycosylation end products: relationship to macrophage receptor for glucose-modified proteins. J Exp Med 1991; 174:515524.MEDLINE
  • 47
    Li YM, Mitsuhashi T, Wojciechowicz D, Shimizu N, Li J, Stitt A, He C, et al. Molecular identity and cellular distribution of advanced glycation end product receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins. Proc Natl Acad Sci U S A 1996; 93:1104711052.MEDLINE
  • 48
    Smedsrod B, Melkko J, Araki N, Sano H, Horiuchi S. Advanced glycation end products are eliminated by scavenger-receptor–mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem J 1997; 322:567573.MEDLINE
  • 49
    Youssef S, Soulis T, Cooper ME. Hepatic advanced glycation endproduct binding is increased in experimental diabetes. Cell Mol Biol (Noisy-le-grand) 1998; 44:10951100.
  • 50
    Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 1994; 269:98899897.MEDLINE
  • 51
    Wiltfang J, Nolte W, Otto M, Wildberg J, Bahn E, Figulla HR, Pralle L, et al. Elevated serum levels of astroglial S100beta in patients with liver cirrhosis indicate early and subclinical portal-systemic encephalopathy. Metab Brain Dis 1999; 14:239251.MEDLINE
  • 52
    Parkkinen J, Raulo E, Merenmies J, Nolo R, Kajander EO, Baumann M, Rauvala H. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Biol Chem 1993; 268:1972619738.MEDLINE
  • 53
    Paradis V, Dargere D, Bonvoust F, Vidaud M, Bedossa P. Connective tissue growth factor (CTGF) is upregulated after high glucose in the liver. Relevance for the pathogenesis of fibrosis development in non-alcoholic steatohepatitis (NASH) [Abstract]. Hepatology 2000; 32:183A.
  • 54
    Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, Oh Y, et al. Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: a potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology 2001; 142:17601769.MEDLINE
  • 55
    Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 1999; 30:968976.MEDLINE
  • 56
    Williams EJ, Gaca MD, Brigstock DR, Arthur MJ, Benyon RC. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol 2000; 32:754761.MEDLINE
  • 57
    Reimann T, Hempel U, Krautwald S, Axmann A, Scheibe R, Seidel D, Wenzel KW. Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett 1997; 403:5760.MEDLINE
  • 58
    Mulder KM. Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev 2000; 11:2335.MEDLINE