• 1
    Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000; 100:157168. MEDLINE
  • 2
    Sell S, Leffert HL. An evaluation of the cellular lineages in the pathogenesis of experimental hepatocellular carcinoma. Hepatology 1982: 2: 7786. MEDLINE
  • 3
    Sell S, Ilic Z. (1997) Liver Stem Cells, Austin, TX: Landis Bioscience 1997; 1347.
  • 4
    Farber E. Similarities in the sequence of early histologic changes induced in the livers by ethionine, 2-acetylaminofluorene and 3'-methyl-4-dimethylaminoazobenzene. Cancer Res 1956; 6:142148.
  • 5
    Farber E. Precancerous steps in carcinogenesis: their physiological adaptive nature. Biochim Biophys Acta 1984; 738:171180. MEDLINE
  • 6
    Novikoff PPM, Yam A, Oikawa I. Blast-like cell compartment in carcinogen-induced proliferating bile ductules. Am J Pathol 1991; 148:14731492.
  • 7
    Paku S, Schnur J, Nagy P, Thorgeirsson SS. Origin and structural evolution of the early proliferating oval cells in rat liver. Am J Pathol 2001; 158:13131323. MEDLINE
  • 8
    Sirica AE, Williams TW. Appearance of ductular hepatocytes in rat liver after bile duct ligation and subsequent zone 3 necrosis by carbon tetrachloride. Am J Pathol 1992; 140:129136. MEDLINE
  • 9
    Petersen BE, Zajac VF, Michalopoulos GK. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatolgy 1998; 27:10301038.
  • 10
    Yin L, Lynch D, Ilic Z, Sell S. Proliferation and differentiation of ductular liver precursor cells and non-parenchymal cells during the restitutive response of the rat liver to carbon tetrachloride injury after inhibition of hepatocyte proliferation by N-2-acetylaminofluorine. Histol Histopathol 2002; 17: 6581. MEDLINE
  • 11
    Sell S. Heterogeneity and plasticity of hepatocyte lineage cells and the origin of hepatocellular carcinoma. Hepatoloogy 2001; 33:738750.
  • 12
    Yavorkovsky L, Lai E, Sell S. Participation of small intraportal “stem” cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol. Hepatology 1995; 21:17021712. MEDLINE
  • 13
    Sell S. Electron microscopic identification of putative liver stem cells and intermediate hepatocytes following periportal necrosis induced in rats by allyl alcohol. Stem Cells 1997; 5:378385.
  • 14
    Yin L, Lynch D, Sell, S. Participation of different cell types in the restitutive response of the rat liver to periportal injury induced by allyl alcohol. J Hepatology 1999; 31:492507.
  • 15
    Leffert HL, Moran T, Sell S, Skelly H, Ibsen K, Mueller M, Arias I. Growth state dependent phenotypes of adult hepatocytes in primary monolayer culture. Proc Natl Acad Sci U S A 1978; 75:18341838. MEDLINE
  • 16
    Rogler LE. Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro. Am J Pathol 1997; 150:591602. MEDLINE
  • 17
    Leffert HL, Koch KS, Moran T, Williams M. Liver Cells. Methods in Enzymology 1979; 53:536544.
  • 18
    Miller AD, Rosman G. Improved retroviral vectors for gene transfer and expression. Bio Techniques 1989; 7:980990.
  • 19
    Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 1993; 90:83928396. MEDLINE
  • 20
    AusubelFM, BrentR, KingstonRE, MooreDD, SeidmanJG, SmithJA, StruhlK (eds). Transduction of genes using retrovirus vectors. In Current Protocols in Molecular Biology, New York: John Wiley & Sons, 1992.
  • 21
    Teutsch HF. Improved method for the histochemical demonstration of glucose-6-phosphatase activity. Histochemistry 1978; 57:107117. MEDLINE
  • 22
    Lojda Z. Studies on dipeptidyl (amino) peptidase IV (Glycyl-Proline Naphthylamidase). Histochemistry 1979; 59:153166. MEDLINE
  • 23
    Rutenberg AM, Kim H, Fischbein JW, Hanker JS, Wasserkrug HL, Seligman AM. Histochemical and ultrastructural demonstration of γ-glutamyl transpeptidase activity. J Histochem Cytochemistry 1969; 17:526.
  • 24
    Omura T, Sato R. Carbon-monoxide-binding pigment of liver microsomes: evidence for its hemoprotein nature. J Bio Chemistry 1964; 239:23792385.
  • 25
    Darzynkiewicz Z, Juan G. DNA content measurement for DNA ploidy and cell cycle analysis. Curr Prot Cytomet 1997:
  • 26
    Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999; 284:19982003. MEDLINE
  • 27
    Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, et al. Fetal liver development requires a paracrine action of oncostatin M through the gp 130 signal transducer. EMBO J 1999; 18:21272136. MEDLINE
  • 28
    Fausto N, Thompson NL, Braun L. In Pretlow TR, Pretlow TP (eds). Purification and culture of oval cells from rat liver. Cell Separation: Methods and Selected Applications, New York: Academic Press, 1987; 4:4577.
  • 29
    Germain L, Noel M, Gourdeau H, Marceau N. Promotion of growth and differentiation of rat ductular oval cells in primary culture. Cancer Res 1988; 48:368378. MEDLINE
  • 30
    Sirica AE, Mathis GA, Sano N, Elmore LW. Isolation, culture, and transplantation of intrahepatic biliary epithelial cells and oval cells. Pathobiology 1990; 58:4464. MEDLINE
  • 31
    Shinozuka H, Lombardi B, Sell S, Iammarino RM. Modification of ethionine liver carcinogenesis by choline deficiency: early histological and functional alterations. Cancer Res 1978; 38:10921098. MEDLINE
  • 32
    Yoskimura H, Harris R, Yokoyama S, Takahashi S, Sells MA, Pan SF, Lombardi B. Anaplastic carcinomas in nude mice and in original donor strain rats inoculated with cultured oval cells. Am J Pathology 1983; 110:322332.
  • 33
    Braun L, Goyette M, Yaswen P, Thompson NL, Fausto N. Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats. Cancer Res 1987; 47:41164124. MEDLINE
  • 34
    Braun L, Mikumo R, Fausto N. Production of hepatocellular carcinoma by oval cells: cell cycle expression of C-myc and p53 at different stages of oval cell transformation. Cancer Res 1989; 49:15541561. MEDLINE
  • 35
    Pack R, Heck R, Dienes HP, Oesch R, Steinberg P. solation, biochemical characterization, long term culture, and phenotype modulation of oval cells from carcinogen-fed rats. Exp Cell Res 1993; 204:198209. MEDLINE
  • 36
    Steinberg P, Steinbrecher R, Radaeva S, Schirmacher P, Dienes HP, Oesch F, Bannasch P. Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-carcinomas and undifferentiated carcinomas after transformation. Laboratory. Investigation 1994; 71:700709.
  • 37
    Radeva S, Steinberg P. Phenotype and differentiation patterns of the oval cell lines OC/CDE 6 and OC/CDE 22 derived from the livers of carcinogen-treated rats. Cancer Res 1995; 55:10281038. MEDLINE
  • 38
    Becker R, Luthgens B, Oesch F, Dienes HP, Steinberg P. Ha-rasVal12 but not p53ser246 leads to a significant neoplastic transformation of the putative rat liver stem cells (oval cell). Carcinogensis 1996; 17:26352640.
  • 39
    Willliams GM, Weisburger EK, Weisburger JH. Isolation and long-term culture of epithelial-like cells from rat liver. Exp Cell Res 1971; 69:106112. MEDLINE
  • 40
    Williams GM, Strombery K, Kroes R. Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver. Laboratory. Investigation 1973; 29:293303.
  • 41
    Koch K, Leffert HL. Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VI. Studies with conditioned medium and its functional interactions with serum factors. J Cell Biology 1974; 62:780791.
  • 42
    McMahon JB, Richards WL, Del Campo AA, Song M-KH, Thorgerisson SS. Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res 1986; 46:46654671. MEDLINE
  • 43
    Grisham E, Coleman WE, Smith GJ. Isolation, culture and transplantation of rat hepatocytic precursor (stem-like) cells. Proc Soc Exp Biol Med 1993; 2004:270279.
  • 44
    Coleman WB, Wenneberg AE, Smith GJ, Grisham JW. Regulation of the differentiation of diploid and some aneuploid rat epithelial (stemlike) cells by the hepatic microenvironment. Am J Pathology 1993; 142:13721382.
  • 45
    Brill S, Zvibel I, Reid LM. Expansion conditions for early hepatic progenitor cells from embryonal and neonatal rat livers. Digestive Disease Science 1999; 44:364371.
  • 46
    Sell S, Osborn K, Leffert HL. Autoradiography of oval cells appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline-devoid diet. Carcinogenesis 1981; 2:714. MEDLINE
  • 47
    Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Sullivan AK, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999; 14:11681170.
  • 48
    Krause DS, Theise ND, Collector, MI, Henegariu O, Hwang S, Gardner R, Neutzel S, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105:369377. MEDLINE
  • 49
    Kinoshita T, Sekiguchi T, Xu M-J, Ito Y, Kamiya A, Tsuji K-I, Nakahata T, Miyajima A. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci U S A 1999; 96:72657270. MEDLINE
  • 50
    Abraham JA, Whang L, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC. Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J 1986; 5:25232528. MEDLINE