Original Articles
You have full text access to this OnlineOpen article
Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, β-catenin expression, and clinical features
Article first published online: 30 DEC 2003
DOI: 10.1053/jhep.2002.35342
Copyright © 2002 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Wei, Y., Van Nhieu, J. T., Prigent, S., Srivatanakul, P., Tiollais, P. and Buendia, M.-A. (2002), Altered expression of E-cadherin in hepatocellular carcinoma: Correlations with genetic alterations, β-catenin expression, and clinical features. Hepatology, 36: 692–701. doi: 10.1053/jhep.2002.35342
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Accepted: 13 JUN 2002
- Manuscript Received: 22 MAR 2002
Funded by
- Association pour la Recherche sur le Cancer. Grant Number: ARC5236
References
- 1, , , , , , . Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 1997; 18:59–65.MEDLINE
- 2, , , , . Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene 1997; 14:2927–2933.MEDLINE
- 3, , , , , , , et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001; 120:1763–1773.MEDLINE
- 4, , , , , , . Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma. Gastroenterology 2001; 121:699–709.MEDLINE
- 5
- 6
- 7, , , , , , , et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000; 24:245–250.MEDLINE
- 8
- 9, , , . Deletion mapping of chromosome 16q in hepatocellular carcinoma. Br J Cancer 1999; 80:850–854.MEDLINE
- 10, , , , , , , et al. Identification of a 1-Mb common region at 16q24.1-24.2 deleted in hepatocellular carcinoma. Genes Chromosomes Cancer 2000; 28:38–44.MEDLINE
- 11, , , , , , , et al. Identification of homozygous deletions at chromosome 16q23 in Aflatoxin B1 exposed hepatocellular carcinoma. Oncogene 2001; 20:5232–5238.MEDLINE
- 12, , , . Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinoma. Hepatology 1996; 23:1441–1447.MEDLINE
- 13, , , , , , , et al. Expression of cadherins and alpha-catenin in primary epithelial tumors of the liver. Gastroenterology 1996; 110:1137–1149.MEDLINE
- 14, , , , , . The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinoma. Int J Cancer 1997; 71:355–359.MEDLINE
- 15, , . Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res 2001; 7:594–599.MEDLINE
- 16. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 1993; 9:317–321.MEDLINE
- 17, . Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. J Cell Biol 1991; 114:319–327.MEDLINE
- 18, , , , , . E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 1998; 142:557–571.MEDLINE
- 19, , . E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 2001; 153:1049–1060.MEDLINE
- 20, , , , . E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci 1999; 112:1237–1245.MEDLINE
- 21
- 22, , , , . E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 2001; 154:1185–1196.MEDLINE
- 23, , , , , , . E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 1995; 14:6107–6115.MEDLINE
- 24
- 25, , , , , , . The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2:84–89.MEDLINE
- 26, . The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 2001; 3:289–293.MEDLINE
- 27, , , , . Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 2000; 275:2727–2732.MEDLINE
- 28, , , , , , , et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 2000; 25:160–165.MEDLINE
- 29, , . An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res 2001; 61:5231–5241.MEDLINE
- 30, , , , , , . E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology 1996; 24:1460–1467.MEDLINE
- 31, , . Histological typing of tumors of the liver. In: International Histological Classification of Tumors. 2nd ed. Berlin: Springer-Verlag, 1994; 11–17.
- 32, , , , , . Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol 1999; 155:703–710.MEDLINE
- 33, . Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. Cytogenet Cell Genet 2000; 88:253–254.MEDLINE
- 34
- 35, , , , , , . E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994; 54:3845–3852.MEDLINE
- 36
- 37, , , , . Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 1997; 272:22322–22329.MEDLINE
- 38, , , , , , . E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas. Oncol Rep 1998; 5:1109–1114.MEDLINE
- 39, , , , , , , et al. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 1993; 53:1690–1695.MEDLINE
- 40, , , , . E-cadherin promotes intraepithelial expansion of bladder carcinoma cells in an in vitro model of carcinoma in situ. Cancer Res 2000; 60:177–183.MEDLINE
- 41, , , , , . Correlation of E-cadherin expression and recurrence of hepatocellular carcinoma. Hepatogastroenterology 1999; 46:1923–1927.MEDLINE
- 42, , , , , , , et al. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma. Gastroenterology 2000; 119:431–440.MEDLINE
- 43, , , . Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated alpha-fetoprotein production. Gastroenterology 1996; 110:184–192.MEDLINE
- 44, , , , , , , et al. Allelic imbalance on 16q in small, unifocal hepatocellular carcinoma: correlation with HBV and HCV infections and cellular proliferation rate. Dig Dis Sci 2000; 45:306–311.MEDLINE
- 45, , , , , , , et al. Comprehensive allelotype study of hepatocellular carcinoma: potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors. Hepatology 2000; 31:1073–1079.MEDLINE
- 46, , , , , , , et al. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995; 55:5195–5199.MEDLINE
- 47, , , , , , . Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 2001; 20:3814–3823.MEDLINE
- 48, , . Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clin Cancer Res 2001; 7:3289–3297.MEDLINE
- 49, , . Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Br J Cancer 2002; 86:98–101.MEDLINE
- 50, , , , , , , et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 2002; 4:222–231.MEDLINE
- 51, , , , . RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol 1998; 18:3647–3658.MEDLINE
- 52
- 53, , , , , , , et al. Close correlation between β-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 1999; 18:6583–6588.MEDLINE

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8)